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Mapping and engineering the human cell–cell interactome
Abstract Efforts to systematically understand how cell interactions tune tissue-level function have motivated transformative advances in single-cell transcriptomics and spatial profiling. Although these technologies can measure molecular states in individual cells and their spatial mapping within tissues, they also reveal that there exists a fundamental knowledge gap of how cells influence each other in context.
Ultrasound priming gated by solid tumor hallmarks to guide CAR-T therapy
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract CAR-T therapy is highly effective in hematologic malignancies but remains challenging in solid tumors.
A wearable non-invasive sonogenetic pacemaker
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Abstract Cardiac pacemakers are critical for treating heart rhythm disorders, but traditional implants are associated with great risks and complications owing to their invasive nature. Here we introduce a wearable non-invasive ultrasound pacemaker (NUP) that activates engineered sonogenetic ion channels (MscL-G22S) to modulate cardiomyocytes, achieving spatiotemporally controlled precise cardiac pacing.
By Chen Gong, Gengxi Lu, Baoqiang Liu, Jie Ji, fan wei, Junhao Lin, Xiao Qing Wan, Songsong Tang, Runze Li, Fengyi Ma, Jaemin Seo, Sunyoung Jung, Jiawen Chen, ShanShan Wang, Shanshan Wang, Junhang Zhang, Xin Sun, Jiarui Wang, Yushun Zeng, Gengle Niu, Xinhao Yang, Xunan Liu, Joshua I. Chalif, Shucong Li, Hsiao-Chuan Liu, Longwei Liu, Hangbo Zhao, jun chen, Yingxiao Wang, Xuanhe Zhao, Qifa Zhou, Z. Phil Che, Christoph G. S. Nabzdyk
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Nature
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