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Georg Martiny-Baron on Muck Rack

Georg Martiny-Baron

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Articles

Single-cell and spatial profiling reveal cDC2A-CXCL13 + CD8 + T-epithelial cell crosstalk and cytotoxicity through TNFRSF9 in cutaneous and mucosal lichen planus

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By Rundong Jiang, Rachael Bogle, Xianying Xing, Jennifer Fox, Paul W. Harms, Tran Thanh Do, Allison C. Billi, J. Michelle Kahlenberg, Robert L. Modlin, Rosane M. Teles, Julie West, Aaron R Mangold, Haihan Zhang, Sandro Bruno, Ben Roediger, Lam C Tsoi, Feriel Hacini-Rachinel, Johann E. Gudjonsson, Joseph Kirma, Georg Martiny-Baron, Till A. Röhn
| Nature Verified
Abstract Lichen planus (LP) is a chronic inflammatory disease of the skin and mucous membranes, marked by T cell infiltration and keratinocyte apoptosis. However, its immune microenvironment remains poorly understood. Using single-cell RNA sequencing, spatial transcriptomics, and proteomics on samples from 28 patients and 18 healthy controls, we identify elevated interferon (IFN) and cytotoxic signatures in CXCL13+CD8+ T cells in both cutaneous and mucosal LP, but not in lichen planopilaris.
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