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Xianying Xing on Muck Rack

Xianying Xing

As seen in: Color Research & Application, Nature, Annals of the Rheumatic Diseases, Cell Press, The Journal of Allergy & Clinical Immunology
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Articles

Single-cell transcriptome reveals keratinocyte subclusters contributing to altered differentiation and inflammatory responses in atopic dermatitis

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By Tingting Qin, Rachael Bogle, Rundong Jiang, Mrinal K. Sarkar, Yuli Cai, Mehrnaz Gharaee-Kermani, Jennifer Fox, Xianying Xing, Sahiti Marella, Mio Nakamura, Emanual Maverakis, Stephanie Le, Alexander A. Merleev, Alina I. Marusina, Cory Simpson, J. Michelle Kahlenberg, Dawn Waterworth, Nina Chi Sabins, Lloyd S. Miller, Tom Freeman, Monica Leung, Marta E. Polak, Lam C Tsoi, Allison C. Billi, Johann E. Gudjonsson, Arti Parihar
| Nature Verified
Abstract Atopic dermatitis (AD) is a common chronic inflammatory skin disease with heterogeneous and poorly understood mechanisms. We perform single-cell RNA sequencing of lesional (LAD) and non-lesional (NAD) skin from 42 AD patients and 23 healthy controls (HC). Keratinocytes (KCs) are the predominant disease-relevant cell type. In healthy skin, KC differentiation follows a linear trajectory from basal KCs through seven differentiated stages to terminal keratinized cells.
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A longitudinal atlas of human psoriatic skin reveals the mechanisms of anti-IL-23 therapy in disrupting the type 17 inflammatory circuit

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By Rundong Jiang, Andrew Blauvelt, Linyu Shi, Lam C Tsoi, Rachael Bogle, Jennifer Fox, Mehrnaz Gharaee-Kermani, Lihong Chen, Haihan Zhang, Xianying Xing, Mrinal K. Sarkar, Olesya Plazyo, J. Michelle Kahlenberg, Allison C. Billi, Robert T. Matheson, Huzefa Photowala, Benjamin D. Ehst, Johann E. Gudjonsson
| Cell Press Verified
Keywords psoriasis risankizumab tissue resident memory T Trm dendritic cell fibroblast endothelial cell IL-23 IL-34 IL-7R Get full text access Log in, subscribe or purchase for full access. References 1. Griffiths, C.E.M. ∙ Armstrong, A.W. ∙ Gudjonsson, J.E. ... Psoriasis Lancet. 2021; 397:1301-1315 2. Armstrong, A.W. ∙ Read, C. Pathophysiology, Clinical Presentation, and Treatment of Psoriasis: A Review JAMA. 2020; 323:1945-1960 3. Ghoreschi, K. ∙ Balato, A. ∙ Enerbäck, C. ...
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Single-cell and spatial profiling reveal cDC2A-CXCL13 + CD8 + T-epithelial cell crosstalk and cytotoxicity through TNFRSF9 in cutaneous and mucosal lichen planus

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By Rundong Jiang, Rachael Bogle, Xianying Xing, Jennifer Fox, Paul W. Harms, Tran Thanh Do, Allison C. Billi, J. Michelle Kahlenberg, Robert L. Modlin, Rosane M. Teles, Julie West, Aaron R Mangold, Haihan Zhang, Sandro Bruno, Ben Roediger, Lam C Tsoi, Feriel Hacini-Rachinel, Johann E. Gudjonsson, Joseph Kirma, Georg Martiny-Baron, Till A. Röhn
| Nature Verified
Abstract Lichen planus (LP) is a chronic inflammatory disease of the skin and mucous membranes, marked by T cell infiltration and keratinocyte apoptosis. However, its immune microenvironment remains poorly understood. Using single-cell RNA sequencing, spatial transcriptomics, and proteomics on samples from 28 patients and 18 healthy controls, we identify elevated interferon (IFN) and cytotoxic signatures in CXCL13+CD8+ T cells in both cutaneous and mucosal LP, but not in lichen planopilaris.
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