George Preston

1 Introduction The development of targeted covalent inhibitors (TCIs) has seen a resurgence in chemical biology and drug discovery over the past decade [1-3]. Although there are a number of TCI-based therapeutics (e.g., penicillin), their covalent mechanism of action was often a serendipitous discovery, whilst the rational design of TCIs has historically been tainted by concerns with off-target reactivity and associated cytotoxicity.

Samsung The Frame now offers over 4000 digitized artworks with new additions from the Tate Collection, Liberty and Art Basel. Samsung's The Frame works as a regular TV when you want to watch movies but doubles as a digital picture frame when it is not in active use. The concept has become popular and has spawned direct competitors in the form of TCL Nxtvision and Hisense Canvas TV.

Composer Mason Bates is one of the premier voices in classical music today, and if his new project goes to plan, he may help foster the next generation of musicmakers. Bates follows up on his blockbuster, award-winning opera about Steve Jobs, with another work focused on the influence of another, different kind of technology.