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Gerhard Leinenga

As seen in: Science Magazine, BioRxiv
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Articles

Scanning ultrasound improves memory and enhances functional outcomes in Alzheimer mice in the absence of amyloid-beta reduction

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By Gerhard Leinenga, Xuan Vinh To, Liviu-Gabriel Bodea, Jumana Yousef
| BioRxiv
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Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model

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By Gerhard Leinenga
| Science Magazine Verified
Transgenic mice with increased amyloid-β (Aβ) production show several aspects of Alzheimer’s disease, including Aβ deposition and memory impairment. By repeatedly treating these Aβ-forming mice with scanning ultrasound, Leinenga and Götz now demonstrate that Aβ is removed and memory is restored as revealed by improvement in three memory tasks.
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PLOS ONE: Scanning Ultrasound (SUS) Causes No Changes to Neuronal Excitability and Prevents Age-Related Reductions in Hippocampal CA1 Dendritic Structure in Wild-Type Mice

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By Robert Hatch, Gerhard Leinenga
| PLOS
Scanning ultrasound (SUS) is a noninvasive approach that has recently been shown to ameliorate histopathological changes and restore memory functions in an Alzheimer's disease mouse model. Although no overt neuronal damage was reported, the short- and long-term effects of SUS on neuronal excitability and dendritic tree morphology had not been investigated.
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