Gerty Schreibelt on Muck Rack

Gerty Schreibelt

As seen in: Nature, BMJ Open, Cell Press
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Articles

Unraveling mutagenic processes influencing the tumor mutational patterns of individuals with constitutional mismatch repair deficiency - Nature Communications

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By Dilys D. Weijers, Gerty Schreibelt, Sjors Middelkamp, Arjen R. Mensenkamp, Ruben van Boxtel, Mark AJ Gorris
| Nature Verified
Abstract Constitutional mismatch repair deficiency (CMMRD), caused by bi-allelic germline variants in mismatch repair (MMR) genes, is associated with high cancer incidence early in life. A better understanding of mutational processes driving sequential CMMRD tumors can advance optimal treatment. Here, we describe a genomic characterization on a representative collection of CMMRD-associated tumors consisting of 41 tumors from 17 individuals.
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Design of TOLERANT: phase I/II safety assessment of intranodal administration of HSP70/mB29a self-peptide antigen-loaded autologous tolerogenic dendritic cells in patients with rheumatoid arthritis

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By Gerty Schreibelt, Bouke J. Koeneman, Arie Jan Stoppelenburg, Evert-Jan Breman
| BMJ Open Verified
Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways. rheumatology immunology clinical trial Echo-guided administration of tolerogenic dendritic cells (tolDCs) into the inguinal lymph node ensures that the cells reach the intended site of action.
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Influence of microbiota-associated metabolic reprogramming on clinical outcome in patients with melanoma from the randomized adjuvant dendritic cell-based MIND-DC trial | Nature Communications

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By Gianmarco Piccinno, Mélanie Bourgin, Gerty Schreibelt, Marine Fidelle, Paolo Manghi, Francesco Asnicar, Bertrand Routy, Damien Drubay, Nicola Segata, Laurence Zitvogel
| Nature Verified
Abstract Tumor immunosurveillance plays a major role in melanoma, prompting the development of immunotherapy strategies. The gut microbiota composition, influencing peripheral and tumoral immune tonus, earned its credentials among predictors of survival in melanoma. The MIND-DC phase III trial (NCT02993315) randomized (2:1 ratio) 148 patients with stage IIIB/C melanoma to adjuvant treatment with autologous natural dendritic cell (nDC) or placebo (PL).
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