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Geum-Sook Hwang on Muck Rack

Geum-Sook Hwang

As seen in: Nature, ACS Publications, Royal Society of Chemistry
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Articles

Intrinsic polyunsaturated fatty acid synthesis capacity dictates ferroptosis sensitivity under restricted arachidonic acid availability

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By Min Kim, Seo Young Jang, Ji-Yoon Lee, Jong Kim, Woosung Jung, Kyoung-Jin Oh, Baek-Soo Han, Kwang-Hee Bae, Mi-Young Kim, Geum-Sook Hwang, Eun-Woo Lee, Yeon-Mi You, Jooeun Kim
| Nature Verified
Abstract Ferroptosis is an iron-dependent type of regulated cell death driven by lipid peroxidation, in which polyunsaturated fatty acids (PUFAs) in membrane phospholipids serve as key substrates. Here, we identify PUFA biosynthetic capacity as a key determinant of ferroptosis sensitivity under arachidonic acid (AA)-limited conditions.
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Stem cell activity is linked to a transient acquisition of pluripotency during callus proliferation

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By Ok-Sun Park, Kyounghee Lee, Hong Gil Lee, Seo Young Jang, Geum-Sook Hwang, Pil Joon Seo, Yoo-Sun Noh
| Nature Verified
Abstract Plant somatic cells can be reprogrammed to form a pluripotent cell mass, known as callus, from which new organs can grow via de novo organogenesis. Here, we show that pluripotency acquisition during callus formation is transient, regardless of explant origin.
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Structural basis for malate-driven, pore lipid-regulated activation of the Arabidopsis vacuolar anion channel ALMT9 - Nature Communications

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By Yeongmok Lee, Jaemin Yoo, Seo Young Jang, Seoyeon Jung, Geum-Sook Hwang, Alexis De Angeli
| Nature Verified
Abstract In plant cells, ALMTs are key plasma and vacuolar membrane-localized anion channels regulating plant responses to the environment. Vacuolar ALMTs control anion accumulation in plant cells and, in guard cells, they regulate stomata aperture. The activation of vacuolar ALMTs depends on voltage and cytosolic malate, but the underlying molecular mechanisms remain elusive.
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