Gianluca Sbardella
Professor at @UniSalerno, Past President of @DCFSCI and Secretary of the @EuroMedChem EC. Epigenetic Medicinal Chemistry and Chemical Biology.
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Dynamic epigenetic regulation of BCLAF1 splicing in acute myeloid leukemia
Abstract Dysregulation of alternative splicing is increasingly associated with cancer development and tumor progression. BCL2-associated transcription factor 1 (BCLAF1) is involved in a wide range of biological processes and it is continuously being investigated due to its intricate function in tumorigenesis and drug resistance.
Ferroptosis and Autophagy-Dependent Cell Death in Oncology Medicinal Chemistry: Call for Papers
Cite Jump to ExpandCollapse EditorialJanuary 8, 2026 Ferroptosis and Autophagy-Dependent Cell Death in Oncology Medicinal Chemistry: Call for Papers Click to copy article linkArticle link copied! Journal of Medicinal Chemistry Cite this: J. Med. Chem.
An Amazing 30-Year Journey around the DABO Family: A Medicinal Chemistry Lesson on a Versatile Class of Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors
Significance Click to copy section linkSection link copied! HIV non-nucleoside reverse transcriptase inhibitors display high potency and specificity combined with low toxicity playing a crucial role in highly active antiretroviral therapies 3,4-Dihydro-2-alkoxy-6-benzyl-4-oxopyrimidines (DABOs) are a family of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) described since 1992 Many authors around the world determined structure–activity relationships optimizing their potency up...
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