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Impact of the gut microbiome on immunological responses to COVID-19 vaccination in healthy controls and people living with HIV - npj Biofilms and Microbiomes
Abstract Although mRNA SARS-CoV-2 vaccines are generally safe and effective, in certain immunocompromised individuals they can elicit poor immunogenic responses. Among these individuals, people living with HIV (PLWH) have poor immunogenicity to several oral and parenteral vaccines.
Riboflavin Supplementation Promotes Butyrate Production in the Absence of Gross Compositional Changes in the Gut Microbiota
Antioxidants & Redox SignalingAhead of Print Open AccessCreative Commons license Abstract Aims: We performed a randomized, placebo-controlled trial, RIBOGUT, to study the effect of 2 weeks supplementation with either 50 or 100 mg/d of riboflavin on (i) Faecalibacterium prausnitzii abundance, (ii) gut microbiota composition, (iii) short-chain fatty acid (SCFA) profiles, and (iv) the satiety and gut hormones. Results: Neither dose of riboflavin, analyzed separately, impacted the abundance of F.
A Secreted Bacterial Peptidylarginine Deiminase Can Neutralize Human Innate Immune Defenses
RESULTS AND DISCUSSIONPPAD impairs bacterial binding and internalization by neutrophils.To verify the relevance of PPAD production in inflamed periodontal tissue, we performed immunohistochemistry using a previously developed PPAD-specific antibody. As shown in Fig. 1b, this allowed us to detect the presence of PPAD in gingival tissues of periodontitis patients for the first time. This observation enticed us to further investigate the interaction of P. gingivalis with key host immune cells.
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