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Articles by Gitalee Sarker
Sympathetic neurons remodel the extracellular matrix for thermogenesis
The cellular microenvironment surrounding sympathetic nerves is emerging as an important regulator of adipose tissue metabolism. A new study published in Nature Metabolism shows that a discrete population of GUSB-expressing sympathetic neurons can modulate adipose thermogenesis by remodelling the extracellular matrix.
RNA-based approaches in the diagnosis and treatment of obesity
Abstract Obesity is a global, complex, and multifactorial disease, and a major risk factor for diabetes, cardiovascular disease, fatty liver disease, and cancer. Despite its high prevalence, effective diagnostic and therapeutic strategies remain limited. Conventional anthropometric measurements, such as body mass index (BMI) and waist circumference, offer limited accuracy in assessing the impact of excess adiposity and related comorbidities on individual patients.
The perineurium integrates leptin with its sympathetic outflow to protect against obesity
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Abstract The regulatory mechanism of leptin’s afferent action in the brain is contingent upon the efferent sympathetic innervation of white and brown adipose tissues. Nonetheless, the peripheral regulation governing the afferent–efferent balance remains ambiguous.
By Gitalee Sarker, Emma Haberman, Anandhakumar Chandran, Thomas Monfeuga, Cyrielle Maroteau, Sofia Lundh, DAVID OLIVEIRA, Andrea Raimondi, Karin A. Ziegler, Tiago A. Gomes, Tiago Cordeiro, Noelia Martínez-Sánchez, Bernardo A. Arús, Yitao Zhu, Michal Shreberk Shaked, Sarah Knowles, Stefan Engelhardt, Matteo Iannacone, Philipp E. Scherer, Miguel Lopez, Miguel López Verified, Enrique M. Toledo, Ana I. Domingos, Karishma Parekh, Emilia Schmid, Paola Fernández-Sanmartín, Alina Griebel, Samson W. Cheung
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Nature
Verified
Defective Olfactomedin-2 connects adipocyte dysfunction to obesity - Nature Communications
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Abstract Olfactomedin-2 (OLFM2) is a pleiotropic glycoprotein emerging as a regulator of energy homeostasis. We here show the expression of OLFM2 to be adipocyte-specific and inversely associated with obesity. OLFM2 levels increase during adipogenesis and are suppressed in inflamed adipocytes. Functionally, OLFM2 deficiency impairs adipocyte differentiation, while its over-production enhances the adipogenic transformation of fat cell progenitors.
By Aina Lluch, Isabel Espadas, Núria Oliveras-Cañellas, José M Moreno-Navarrete, Estefanía Caballano-Infantes, Gitalee Sarker, Pablo Garrido-Gil, Naoki Nakaya, Silvia Mora, María M. Malagón, Alejandro Martin-Montalvo, You Zhou, Ana I. Domingos, Miguel Lopez, Miguel López Verified, María Gómez-Serrano, Witold Szymanski, Johannes Graumann, Stanislav I. Tomarev, Ismael González-García, José M. Fernández-Real
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Nature
Verified
The perineurium integrates leptin with its sympathetic outflow to protect against obesity
Abstract The regulatory mechanism of leptin's afferent action in the brain, constituting a negative feedback loop, is contingent upon the efferent sympathetic innervation of white and brown adipose tissues. Nonetheless, the peripheral regulation governing the relative strengths of the afferent and efferent arms remains ambiguous.
Immunomodulatory leptin receptor+ sympathetic perineurial barrier cells protect against obesity by facilitating brown adipose tissue thermogenesis
O’Brien C.J.O. Haberman E.R. Domingos A.I. A tale of three systems: toward a neuroimmunoendocrine model of obesity. Annu. Rev. Cell Dev. Biol. 2021; 37: 549-573 Weisberg S.P. McCann D. Desai M. Rosenbaum M. Leibel R.L. Ferrante A.W. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 2003; 112: 1796-1808 Pirzgalska R.M. Seixas E. Seidman J.S. Link V.M. Sánchez N.M. Mahú I. Mendes R. Gres V. Kubasova N. Morris I. et al.
Immunomodulatory Leptin Receptor+ Sympathetic Perineurial Cells Protect Against Obesity by Facilitating Neuroendocrine-Mediated Brown Adipose Tissue Thermogenesis
Abstract Adipose tissues (ATs) are innervated by sympathetic nerves, which drive reduction of fat mass via lipolysis and thermogenesis. Here, we report a population of immunomodulatory leptin receptor (LepR)-expressing barrier cells which ensheath sympathetic axon bundles in adipose tissues. These LepR-expressing Sympathetic Perineurial Cells (SPCs) produce IL33, a factor for maintenance and recruitment of regulatory T cell (Treg) and eosinophils in AT.
ILC3s gut rhythm
Group 3 innate lymphoid cells (ILC3s) are critical for maintaining gut epithelial integrity and tissue repair. Recent research identifies mechanisms by which circadian machinery and feeding behavior regulate enteric ILC3s to maintain gut homeostasis. Fig. 1: Neuroimmune regulation of ILC3s in the gut. References 1. Seillet, C. et al. Nat. Immunol. https://doi.org/10.1038/s41590-019-0567-y (2019). 2. Godinho-Silva, C. et al. Nature 574, 254–258 (2019). 3. Spits, H. et al. Nat. Rev. Immunol. 13, 145–149 (2013). 4.
Maternal overnutrition during critical developmental periods leads to different health adversities in the offspring: relevance of obesity, addiction and schizophrenia
Abstract Maternal overnutrition during sensitive periods of early development increases the risk for obesity and neuropsychiatric disorders later in life. However, it still remains unclear during which phases of early development the offspring is more vulnerable. Here, we investigate the effects of maternal high-fat diet (MHFD) at different stages of pre- or postnatal development and characterize the behavioral, neurochemical and metabolic phenotypes.
Eating for two? Feeding habits during pregnancy may have lasting consequences
Obesity and substance abuse represent two of the major public health issues of this millennium, having a deleterious impact on our morbidity, mortality and health expenditure. According to WHO in 2016, approximately 1.9 billion adults are overweight and 650 million among them are obese. In addition, according to the World Drug Report 2018, around 275 million people worldwide have been reported to have used an illicit drug at least once in 2016.
Transgenerational transmission of hedonic behaviors and metabolic phenotypes induced by maternal overnutrition
C57BL/6N mice (10 weeks old) were obtained from Charles River, Germany. Mice were acclimatized for 2 weeks in a temperature and humidity controlled facility under a reversed light-dark cycle (lights off: 7:00–19:00) with chow food (Kliba-Nafag 3430, Klibamühlen; major nutrients: 18.5% crude protein, dry matter 88%, crude fat 4.5%, 54.2% NFE) and water ad libitum.
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