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Giuseppe Longobardi on Muck Rack

Giuseppe Longobardi

As seen in: Nature, ACS Publications, The Times of Israel, QOSHE
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Articles

The Blogs: Beyond Fear: Building Brain Therapies in Israel During a National Crisis

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By Giuseppe Longobardi
| The Times of Israel Verified
My journey to Israel began with curiosity. During my PhD in Pharmaceutical Sciences at the University of Naples Federico II in Italy, my PhD supervisor encouraged me to pursue an international secondment. That decision brought me to Israel for a year as a visiting PhD student in the laboratory of Prof. Ronit Satchi-Fainaro at Tel Aviv University, drawn by the lab’s international reputation in nanomedicine and drug delivery and by Israel’s culture of scientific innovation.
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p53 inactivation drives breast cancer metastasis to the brain through SCD1 upregulation and increased fatty acid metabolism - Nature Genetics

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By Tom Winkler, Alessia Ricci, Giuseppe Longobardi, Shai Ovadia, Katharina Lange, Jean Berthelet, Sahar Israeli Dangoor, Karolina Szczepanowska, Sergey Malitsky, Thomas Broggini, Delphine Merino, Ayelet Erez, Hind Medyouf, Luca Bertero, Ronit Satchi-Fainaro
| Nature Verified
Abstract Brain metastasis (BM) carries a poor prognosis, yet the molecular basis of brain tropism remains unclear. Analysis of breast cancer BM (BCBM) revealed pervasive p53 inactivation through mutations and/or aneuploidy, with pathway disruption already present in primary tumors. Functionally, p53 inactivation markedly increased BCBM formation and growth in vivo, causally linking p53 perturbation to BM.
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Development and Nanoparticle-Mediated Delivery of Novel MDM2/MDM4 Heterodimer Peptide Inhibitors to Enhance 5-Fluorouracil Nucleolar Stress in Colorectal Cancer Cells

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By Francesco Merlino, Annalisa Pecoraro, Giuseppe Longobardi, Greta Donati
| ACS Publications
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