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Luca Bertero on Muck Rack

Luca Bertero

As seen in: British Journal of Cancer, Color Research & Application, Nature, Journal of Clinical Pathology, MDPI, Taylor & Francis Online, Journal of Translational Medicine, Canadian Journal of Infectious Diseases & Medical Microbiology, Physician's Weekly, EJSO - European Journal of Surgical Oncology
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Articles

Hetairos is a histology-based artificial intelligence model for predicting central nervous system tumor methylation subtypes

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By Darui Jin, Artem Shmatko, Areeba Patel, Samuel Rutz, Lukas Friedrich, Rouzbeh Banan, Ramin Rahmanzade, Philipp Sievers, Stefan Hamelmann, Daniel Schrimpf, Kirsten Göbel, Sybren L. N. Maas, Martin Sill, Felix Hinz, Abigail K. Suwala, Felix Keller, Antje Habel, Gleb D. Rukhovich, Ferdinand Zettl, Obada T. Alhalabi, Sebastian Ille, Jannik Sehring, Daniel Amsel, Benedikt Wiestler, Pedro Lago, Bogdana Suchorska, Dominik Sturm, David E. Reuss, Pieter Wesseling, Frank L. Heppner, Ingmar Blümcke, Claire Delbridge, Martin Jakobs, Christel Herold-Mende, Sandro M. Krieg, Wolfgang Wick, David Jones, Stefan M. Pfister, Maysa Al-Hussaini, Yanghao Hou, Felipe D’Almeida Costa, Leonille Schweizer, Luca Bertero, Arnault Tauziède-Espariat, Pascale Varlet, Doron Merkler, Kristof Egervari, Hildegard Dohmen, Roger Gejman, Sebastian Brandner, Xiangzhi Bai, Andreas von Deimling, Felix Sahm, Moritz Gerstung, Henri Bogumil, Olfat Ahmad, Adelheid Wöhrer, Pablo Zoroquiain
| Nature Verified
Abstract Molecular testing is essential for classifying central nervous system (CNS) tumors, with methylation profiling providing the highest diagnostic granularity. However, this requires more resources and time than conventional hematoxylin and eosin (H&E) histopathology, which is widely available globally. Here we propose Hetairos, an artificial intelligence algorithm that predicts 102 methylation-based CNS tumor subtypes from digital H&E slides.
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p53 inactivation drives breast cancer metastasis to the brain through SCD1 upregulation and increased fatty acid metabolism - Nature Genetics

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By Tom Winkler, Alessia Ricci, Giuseppe Longobardi, Shai Ovadia, Katharina Lange, Jean Berthelet, Sahar Israeli Dangoor, Karolina Szczepanowska, Sergey Malitsky, Thomas Broggini, Delphine Merino, Ayelet Erez, Hind Medyouf, Luca Bertero, Ronit Satchi-Fainaro
| Nature Verified
Abstract Brain metastasis (BM) carries a poor prognosis, yet the molecular basis of brain tropism remains unclear. Analysis of breast cancer BM (BCBM) revealed pervasive p53 inactivation through mutations and/or aneuploidy, with pathway disruption already present in primary tumors. Functionally, p53 inactivation markedly increased BCBM formation and growth in vivo, causally linking p53 perturbation to BM.
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Growth Hormone-Secreting Pituitary Adenoma: Dura Mater Invasion Is Not a Predictor of Acromegaly Persistence After Trans-Sphenoidal Surgery

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By Nunzia Prencipe, Emanuele Varaldo, Luca Bertero, Giuseppe Di Perna
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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