Gorbatchev Ambroise

Abstract Background Deubiquitinating enzymes (DUBs) are linked to cancer progression and dissemination, yet less is known about their regulation and impact on epithelial–mesenchymal transition (EMT). Methods An integrative translational approach combining systematic computational analyses of The Cancer Genome Atlas cancer cohorts with CRISPR genetics, biochemistry and immunohistochemistry methodologies to identify and assess the role of human DUBs in EMT.

Expression of PHGDH Is Associated with Lung Adenocarcinoma Prognosis The Relevance of PHGDH to Lung Adenocarcinoma Cell Proliferation, Survival, and Tumorigenicity Increased Abundance of Transcripts Encoding the Serine Pathway Associates with the Biosynthetic Pathways of Glutathione, Purines, and Pyrimidines in Primary Tumor Biopsies Differential PHGDH Protein Levels Can Be Defined by Proteasomal Degradation, and the Deubiquitinating Enzyme JOSD2 Is a Regulator of Its Protein Stability The...