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Articles

Convergent MurJ flippase inhibition by phage lysis proteins - Nature

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By Yancheng E. Li, Grace Baron, Karthik Chamakura, Ry Young, William M. Jr, S. Francesca Antillon
| Nature Verified
Abstract Antimicrobial drug resistance poses a global health challenge that necessitates the identification of new druggable targets1,2,3. The essential lipid II flippase MurJ is a promising yet underexplored antimicrobial target in bacterial cell wall biosynthesis4,5,6,7. The only known inhibitors of Gram-negative (diderm) MurJ are the single-gene lysis proteins (Sgls) from the lytic single-strand RNA phages M (SglM) and PP7 (SglPP7)8,9.
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Tennessee has a housing problem. Here's how you can help | Opinion Original

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By Grace Baron
| The Tennessean Verified
Why has housing become unaffordable almost everywhere in Tennessee — urban, suburban and rural communities alike? The short version: This is a story of supply and demand. Tennessee has more residents than ever, and there for everyone who wants one. Since 2010, Tennessee's population has grown by — mostly from new people moving to the state. Meanwhile, new home construction reached an all-time low during the Great Recession and never fully recovered.
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