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Grazia Annesi

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Articles

Genetic variation in antidiabetic drug targets: associations with Parkinson’s disease risk and age at onset

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By Katalin Vincze, Alexander Ploner, Robert Karlsson, Xiaoying Kang, Bowen Tang, Chenxi Qin, Cloé Domenighetti, Pierre-Emmanuel Sugier, Claudia Schulte, Patrick May, Dheeraj Reddy Bobbili, Milena Radivojkov-Blagojevic, Peter Lichtner, Andrew Singleton, Dena Hernandez, Connor Edsall, George D. Mellick, Alexander Zimprich, Walter Pirker, Ekaterina Rogaeva, Anthony E Lang, Sulev Kõks, Pille Taba, Suzanne Lesage, Alexis Brice, Jean-Christophe Corvol, Marie-Christine Chartier-Harlin, Eugénie Mutez, Kathrin Brockmann, Angela B. Deutschländer, Lena F. Burbulla, Georges M. Hadjigeorgiou, Efthimos Dardiotis, Leonidas Stefanis, Athina Maria Simitsi, Enza Maria Valente, Simona Petrucci, Letizia Straniero, Anna Zecchinelli, Gianni Pezzoli, Laura Brighina, Carlo Ferrarese, Grazia Annesi, Andrea Quattrone, Monica Gagliardi, Hirotaka Matsuo, Akiyoshi Nakayama, Nobutaka Hattori, Kenya Nishioka, Sun Ju Chung, Yun Joong Kim, Pierre Kolber, Bastiaan R Bloem, Mathias Toft, Lasse Pihlstrøm, Leonor Correia Guedes, Joaquim J Ferreira, Soraya Bardien, Jonathan Carr, Eduardo Tolosa, Mario Ezquerra, Caroline Ran, Andrea C. Belin, Andreas Puschmann, Carl Clarke, Karen Morrison Verified, Manuela MX Tan, Dimitri Krainc, Matt J. Farrer, Zied Landoulsi, Rejko Kruger, Thomas Gasser, Alexis Elbaz, Manu Sharma, Nancy L Pedersen, Sofia Carlsson, Sara Hägg, Karin Wirdefeldt, Agnieszka Szwajda, Bart PC Van de Warrenburg
| Nature Verified
Abstract To investigate whether antidiabetic drugs have a biological basis to be repurposed in PD prevention, we applied a drug target Mendelian randomization framework to assess associations between genetic variation in antidiabetic drug targets and PD risk or age at onset (AAO).
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Genome-wide association study of copy number variations in Parkinson’s disease

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By Zied Landoulsi, Nicole Kuznetsov, Claudia Schulte, Ludovica Montanucci, Costin Leu, Lisa-Marie Niestroj, Emadeldin Hassanin, Cloé Domenighetti, Pierre-Emmanuel Sugier, Peter Lichtner, Jens Krüger, Dena Hernandez, Cornelis Blauwendraat, George D. Mellick, Alexander Zimprich, Walter Pirker, Manuela MX Tan, Ekaterina Rogaeva, Anthony E Lang, Sulev Kõks, Pille Taba, Suzanne Lesage, Alexis Brice, Jean-Christophe Corvol, Marie-Christine Chartier-Harlin, Eugénie Mutez, Kathrin Brockmann, Angela B. Deutschländer, Leonidas Stefanis, Athina Maria Simitsi, Enza Maria Valente, Simona Petrucci, Letizia Straniero, Anna Zecchinelli, Gianni Pezzoli, Laura Brighina, Carlo Ferrarese, Andrea Quattrone, Monica Gagliardi, Lena F. Burbulla, Hirotaka Matsuo, Akiyoshi Nakayama, Nobutaka Hattori, Kenya Nishioka, Sun Ju Chung, Yun Joong Kim, Lukas Pavelka, Pierre Kolber, Bastiaan R Bloem, Andrew Singleton, Dan M. Vitale, Mathias Toft, Lasse Pihlstrom, Leonor Correia Guedes, Joaquim J Ferreira, Soraya Bardien, Jonathan Carr, Eduardo Tolosa, Mario Ezquerra, Karin Wirdefeldt, Nancy L Pedersen, Caroline Ran, Andrea C. Belin, Andreas Puschmann, Carl Clarke, Karen Morrison Verified, Dimitri Krainc, Dennis Lal, Alexis Elbaz, Thomas Gasser, Rejko Kruger, MANU SHARMA, Patrick May, Dheeraj Reddy Bobbili, Milena Radivojkov-Blagojevic, Connor Edsall, Georges M. Hadjigeorgiou, Efthimos Dardiotis, Grazia Annesi, Matt J. Farrer
| Nature Verified
Abstract We investigated the role of copy number variations (CNVs) in Parkinson’s disease (PD) using genotyping data from 10,815 patients (2731 early-onset PD, EOPD) and 8901 controls from the COURAGE-PD consortium. CNVs were analyzed using a sliding window genome-wide association and burden approach.
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