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As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Articles
Genetic variation in antidiabetic drug targets: associations with Parkinson’s disease risk and age at onset
Abstract To investigate whether antidiabetic drugs have a biological basis to be repurposed in PD prevention, we applied a drug target Mendelian randomization framework to assess associations between genetic variation in antidiabetic drug targets and PD risk or age at onset (AAO).
Multi-locus genetic dosage shapes cognitive disease progression in Parkinson’s patients: 15-year meta-analysis of 24 cohorts
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Abstract Progression from Parkinson’s disease (PD) to Lewy body dementia is a major clinical concern. Although several progression-associated loci have been identified, their cumulative effects on cognitive decline have not been systematically evaluated.
By Xiaoying Kang, Zechuan Lin, Lauren Miller, Sofia Soriano, Joseph J Locascio, Jean-Christophe Corvol, Jodi Maple-Grødem, Yangyi Fan, Meghan Campbell, Alexis Elbaz, Suzanne Lesage, Alexis Brice, Albert Y. Hung, Michael A. Schwarzschild, Michael Hayes, Anne-Marie Wills, Todd Herrington, Ganqiang Liu, Bernard M. Ravina, Pille Taba, Sulev Kõks, Tanya Simuni, Lars Forsgren, Carl Counsell, Angus D Macleod, Thomas G Beach, Guido Alves, Ole-Bjørn Tysnes, Joel S. Perlmutter, Peter Heutink, Meike Kasten, Brit Mollenhauer, Claudia Trenkwalder, Christine A. Klein, Dagmar H. Hepp, David Cassini Backstrom, Per Svenningsson, Michele T. Hu, Caroline H. Williams-Gray, Roger Barker, Clemens R. Scherzer, Fatma Zehra Calikusu, Kara Mead
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Nature
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A hierarchical theranostic nanoagent for multimodal imaging and targeted foam cell intervention in atherosclerosis
Abstract Atherosclerosis (AS) is a leading cause of cardiovascular and cerebrovascular disease and is driven by lipid accumulation and chronic inflammation within arterial plaques. Foam cells play a central role in plaque growth and destabilization, yet their precise diagnosis and targeted regulation remain challenging. Here we present a hierarchical nanoagent that integrates multimodal imaging with selective foam cell intervention for improved AS management.
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