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Grennady Wirjanata on Muck Rack

Grennady Wirjanata

As seen in: Nature, BioRxiv, The Journal of Biological Chemistry
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Articles

Identification and structural validation of purine nucleoside phosphorylase from Plasmodium falciparum as a target of MMV00848

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By Zara Chung, Nanyang Technological, Jianqing Lin, Grennady Wirjanata
| The Journal of Biological Chemistry Verified
Abstract About 247 million cases of malaria occurred in 2021 with P. falciparum accounting for the majority of 619,000 deaths. In the absence of a widely available vaccine, chemotherapy remains crucial to prevent, treat and contain the disease. The efficacy of several drugs currently used in the clinic is likely to suffer from the emergence of resistant parasites.
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Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development

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By Grennady Wirjanata, Jianqing Lin, Jerzy Michal Dziekan, Zara Chung
| BioRxiv
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
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Cellular thermal shift assay for the identification of drug-target interactions in the Plasmodium falciparum proteome

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By Lingyun Dai, Liyan Chen, Jerzy Michal Dziekan, Grennady Wirjanata
| Nature Verified
Abstract Despite decades of research, little is known about the cellular targets and the mode of action of the vast majority of antimalarial drugs. We recently demonstrated that the cellular thermal shift assay (CETSA) protocol in its two variants: the melt curve and the isothermal dose-response, represents a comprehensive strategy for the identification of antimalarial drug targets.
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