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Magnesium sensing via LFA-1 regulates CD8+ T cell effector function

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By Jonas Lötscher, Nicole Kirchhammer, Elisabetta Cribioli, Greta Giordano
| Cell Press Verified
Highlights • LFA-1 mediated co-stimulation of CD8+ T cells depends on extracellular magnesium • Magnesium is sensed via LFA-1 and regulates the effector function of CD8+ T cells • Low serum magnesium levels are associated with worse outcomes in cancer immunotherapy • The magnesium-LFA-1 axis has translational potential Summary The relevance of extracellular magnesium in cellular immunity remains largely unknown.
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