Grygoriy Tsenov

Submitted: 21 January 2026 You are already at the latest version Pregnanolone glutamate (PG) is a synthetic neurosteroid analog showing promise for treating ischemic brain injury, yet its blood–brain barrier (BBB) transport and metabolic fate remain unclear. We investigated the pharmacokinetics of PG in postnatal day 12 rats of both sexes subjected to ET‑1–induced focal hippocampal ischemia.

1 Introduction Since their introduction into clinical practice, benzodiazepines (BZDs) have been among the most widely used drugs, and their stable efficacy throughout development has been documented in both clinical and preclinical studies (for review, see Farrell, 1986; Kubova, 1999). They are used for a wide range of medical indications in all patient age groups, including neonates (Rennie and Boylan, 2003).