Guangying Qi

1 INTRODUCTION Tumour microenvironment (TME) is the environment in which tumours develop, grow and metastasize.1 Thus, the TME is a key element in cancer progression, including tumour initiation, metastasis and resistance to treatment.2 The TME comprises cancer cells and various stromal cells, such as fibroblasts, neutrophils, macrophages and other immune cells.3 Tumour-associated macrophages (TAMs) are an extremely heterogeneous population that display proinflammatory and anti-inflammatory...

References Qi L, Lu Z, Sun YH, Song HT, Xu WK. TRIM16 suppresses the progression of prostate tumors by inhibiting the snail signaling pathway. Int J Mol Med. 2016;38(6):1734–42. https://doi.org/10.3892/ijmm.2016.2774. Article CAS PubMed PubMed Central Google Scholar Song L, Qiao G, Yu J, et al. Hsa_circ_0003998 promotes epithelial to mesenchymal transition of hepatocellular carcinoma by sponging mir-143-3p and PCBP1. J Exp Clin Cancer Res. 2020;39:114. https://doi.org/10.1186/s13046-020-01576-0.

Article Info Publication History Accepted: June 22, 2020 Received in revised form: June 13, 2020 Received: February 5, 2020 Publication stage In Press Journal Pre-Proof Footnotes CONFLICT OF INTEREST: none AUTHOR CONTRIBUTIONS S.G.Z. conceived the project and supervised all the experiments; Y.L. performed experiments, analyzed the data and wrote the manuscript with help from F.H., J.L., Q.G.Y., J.A.B. and S.G.Z. Identification DOI: https://doi.org/10.1016/j.jaci.2020.06.029 Copyright © 2020...