Gue-ho Hwang on Muck Rack

Gue-ho Hwang

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Articles

Large DNA deletions occur during DNA repair at 20-fold lower frequency for base editors and prime editors than for Cas9 nucleases - Nature Biomedical Engineering

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By Gue-ho Hwang, Hyeon-Ki Jang, Chan Kim
| Nature Verified
Abstract When used to edit genomes, Cas9 nucleases produce targeted double-strand breaks in DNA. Subsequent DNA-repair pathways can induce large genomic deletions (larger than 100 bp), which constrains the applicability of genome editing.
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Bystander base editing interferes with visual function restoration in Leber congenital amaurosis

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By Seok-Hoon Lee, Jun Wu, Dongjoon Im, Gue-ho Hwang
| biorxiv.org
Abstract Base editors (BEs) have emerged as a powerful tool for gene correction with high activity. However, bystander base editing, a byproduct of BEs, presents challenges for precise editing. Here, we investigated the effects of bystander edits on phenotypic restoration in the context of Leber congenital amaurosis (LCA), a hereditary retinal disorder, as a therapeutic model.
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Author Correction: Enhancing genome editing in hPSCs through dual inhibition of DNA damage response and repair pathways - Nature Communications

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By Ju-Chan Park, Yun-Jeong Kim, Gue-ho Hwang, Sangsu Bae
| Nature Verified
Correction to: Nature Communications https://doi.org/10.1038/s41467-024-48111-9, published online 11 May 2024 In the Acknowledgements section of this article, the grant number relating to the Ministry of Food and Drug Safety was incorrectly given as #1475014063 and should have been 22202MFDS127. The original article has been corrected.
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