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Articles by Gui-Lan Chen
A role for TMEM63 in the lung
Abstract Surfactants are essential for breathing. Although major progress has been made in the past half century toward an understanding of surfactant secretion mechanisms, the identity of the mechanosensor that couples breathing to surfactant secretion has remained elusive. In this issue of the JCI, Chen, Li, and colleagues provide evidence that the mechanosensor is the transmembrane 63 (TMEM63) ion channel. These findings open new avenues for future research into lung mechanobiology.
Mechanosensitive channels TMEM63A and TMEM63B mediate lung inflation-induced surfactant secretion
ResearchPulmonology Open Access | 10.1172/JCI174508 J Clin Invest. https://doi.org/10.1172/JCI174508. Copyright © 2023, Chen et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Pulmonary surfactant is a lipoprotein complex lining the alveolar surface to decrease the surface tension and facilitate inspiration.
To Be or Not to Be an Ion Channel: Cryo-EM Structures Have a Say
Abstract : Ion channels are the second largest class of drug targets after G protein-coupled receptors. In addition to well-recognized ones like voltage-gated Na/K/Ca channels in the heart and neurons, novel ion channels are continuously discovered in both excitable and non-excitable cells and demonstrated to play important roles in many physiological processes and diseases such as developmental disorders, neurodegenerative diseases, and cancer.
Sphingosine-1-Phosphate Signaling in Cardiovascular Diseases
Abstract : Sphingosine-1-phosphate (S1P) is an important sphingolipid molecule involved in regulating cardiovascular functions in physiological and pathological conditions by binding and activating the three G protein-coupled receptors (S1PR1, S1PR2, and S1PR3) expressed in endothelial and smooth muscle cells, as well as cardiomyocytes and fibroblasts. It exerts its actions through various downstream signaling pathways mediating cell proliferation, migration, differentiation, and apoptosis.
Autosomal recessive renal tubular dysgenesis: The need for clinical vigilance in anuric fetuses with normal renal sonography
The effect of nettle vaginal cream on subjective symptoms of vaginal atrophy in postmenopausal women
Unexplained severe polyhydramnios: remember Bartter syndrome
Polyhydramnios occurs in 1-2% pregnancies []. In about 5% of cases the polyhydramnios is severe. There are generally two major etiologies: reduced fetal swallowing and increased fetal urination. Severe and persistent polyhydramnios is an adverse sign for a pregnancy. This is largely due to two factors: the likely presence of an underlying abnormality associated with polyhydramnios and the increased incidence of preterm labor caused by increased uterine pressure.
Aicardi-Goutières syndrome: The need for clinical vigilance in fetuses with sonographic features of congenital infection
Aicardi-Goutières syndrome (AGS) is a genetic disorder that mainly affects the brain, immune system and skin. Most affected newborns show no signs or symptoms. Within the first year of life, patients will develop an episode of severe brain dysfunction (encephalopathy) that is usually severe. We here describe a case of AGS mimicking a congenital infection in utero caused by variants in RNASEH2C.
Sotos syndrome: a study of antenatal presentation
Footnotes 1 These two authors contributed equally to this study. Prenatal Diagnostic Center, Guangzhou Women and Children’s Medical Center affiliated to Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, Guangdong, China
Prenatal microcephaly: Exome sequencing aids rapid determination of causative etiologies
Microcephaly is an etiologically heterogeneous group of conditions defined as a small head circumference (HC) present at birth or later in life. Although it is a descriptive diagnosis, microcephaly is associated with intellectual disability and neurological abnormalities. Prenatal diagnosis of microcephaly can sometimes be made by ultrasound, defined as HC smaller ≤ 3 standard deviations (SDs) below the mean [ [1] Gelber S.E. Grünebaum A.
Early prenatal diagnosis of cleft lip and palate in a Chinese woman with a mosaic CDH1 variant
Min Pan 1 Author Footnotes 1 The two authors contributed equally to this study. Min Pan Footnotes 1 The two authors contributed equally to this study. Affiliations Prenatal Diagnostic Center, Guangzhou Women and Children’s Medical Center, Guangzhou, Guangdong, China Search for articles by this author Gui-Lan Chen 1 Author Footnotes 1 The two authors contributed equally to this study. Gui-Lan Chen Footnotes 1 The two authors contributed equally to this study.
Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function
Abstract The transient receptor potential canonical subfamily member 5 (TRPC5), one of seven mammalian TRPC members, is a nonselective calcium-permeant cation channel. TRPC5 is of considerable interest as a drug target in the treatment of progressive kidney disease, depression, and anxiety. Here, we present the 2.8-Å resolution cryo–electron microscopy (cryo-EM) structure of the mouse TRPC5 (mTRPC5) homotetramer.
ORAI channels are critical for receptor-mediated endocytosis of albumin
Akita type 1 diabetic mice (C57BL/6-Ins2Akita/J) were obtained from the Jackson laboratories and bred at Lund University. For the streptozotocin (STZ)-induced type 1 diabetic model, adult C57BL/6?J mice were administered STZ (Sigma-Aldrich; 55?mg?kg?1 body weight, pH 4.5) or citrate buffer (vehicle) by intraperitoneal (i.p.) injections once a day for 5 days.
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