Guillaume E. Jacot on Muck Rack

Guillaume E. Jacot

As seen in: Cell Metabolism, The Journal of Clinical Investigation
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Articles

Mitochondrial calcium uptake declines during aging and is directly activated by oleuropein to boost energy metabolism and skeletal muscle performance

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By Gaia Gherardi, Anna Weiser, Flavien Bermont, Eugenia Migliavacca, Benjamin Brinon, Guillaume E. Jacot, Aurélie Hermant, Mattia Sturlese, Leonardo Nogara, Filippo Vascon, Agnese De Mario, Andrea Mattarei, Emma Garratt, Mark Burton, Karen A Lillycrop, Keith Godfrey, Laura Cendron, Denis Barron, Stefano Moro, Bert Blaauw, Rosario Rizzuto, Jerome N. Feige, Cristina Mammucari, Umberto De Marchi
| Cell Metabolism Verified
Keywords mitochondria calcium signaling skeletal muscle MCU MCUR1 aging sarcopenia polyphenols fatigue energy endurance Introduction Cellular energy production relies in large part on oxidative metabolism and ATP synthesis in mitochondria.
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Nicotinamide and pyridoxine stimulate muscle stem cell expansion and enhance regenerative capacity during aging

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By Sara Ancel, Joris Michaud, Eugenia Migliavacca, Charline Jomard, Pauline Viardot García, Sonia Karaz, Thibaut Desgeorges, Loic Tauzin, Yann Ratinaud, Benjamin Brinon, Sylviane Metairon, Aurélie Fessard, Sruthi Raja, Guillaume E. Jacot, José L. Sánchez-García
| The Journal of Clinical Investigation
Abstract Skeletal muscle relies on resident muscle stem cells (MuSCs) for growth and repair. Aging and muscle diseases impair MuSC function, leading to stem cell exhaustion and regenerative decline that contribute to the progressive loss of skeletal muscle mass and strength.
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