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Articles by Guoping Ren
The genomic and proteomic landscape of Chinese familial prostate cancer reveals unique mutational signatures and targetable pathways
Abstract Prostate cancer in Chinese men presents distinct molecular features compared with Western populations, yet the genomic basis of familial cases remains poorly defined. Here, we present the first integrated genomic and proteomic profile of 108 Chinese familial prostate cancers versus matched sporadic controls.
Impact of antiseizure medication taper on electroencephalographic dynamics in focal epilepsy: A stereoelectroencephalographic study
The seizure onset zone remains spatially stable during ASM tapering, whereas seizure frequency, propagation, and duration increase at low dosage. The rate of ASM tapering does not impact localization accuracy. The rate and spatial extent of interictal epileptic discharges remain comparable during ASM tapering but show vigilance-dependent modulation.
Family Resilience and Quality of Life Among Chinese Patients With Acute Leukaemia: A Moderated Mediation Model of Cognitive Appraisal and Coping Style
Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. The data are not publicly available due to privacy or ethical restrictions.
The Awakening Brain is Characterized by a Widespread and Spatiotemporally Heterogeneous Increase in High Frequencies
Intracranial EEG and Scalp EEG Recordings An average of 11.5 ± 4.3 depth MNI SEEG electrodes (9 contacts of 0.5–1 mm, distance between contacts 5 mm; 4 patients) or DIXI SEEG electrodes (10–15 contacts of 2 mm, distance between contacts 1.5 mm; 14 patients) were stereotactically implanted in every patient.
Restoration of Ecological Connectivity in Zhaotong City Under the Interference of Human Activities
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Study on the Fracture of a Shield Segment in a Fully Excavated Hard Rock Section under the Influence of Construction Loads
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Mechanism and Influence of Dispersants on the Action of Polymer Flocculants Used in Slurry Separation
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
The Omicron variant BQ.1* with mutations at positions 28,311 and 28,312 in the SARS-CoV-2 N gene have minimal impact on CDC N1 target detection
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Dual block HER2 assessment increased HER2 immunohistochemistry positive rate in resected specimens of gastric cancer: a prospective multicenter clinical trial from China | Diagnostic Pathology | Full Text
This is a prospective multi institutional study based on real world data. It is also a follow-up study of our previous single center studies. To our knowledge, this is the first multi-center study to explore the value of multiple-block HER2 assessment in GC. The results showed that HER2 positive rate and equivocal rate was increased by dual block assessment and meanwhile the HER2 negative rate was decreased. These findings were confirmed in total patients as well as in each hospital.
Self-replicating Biophotoelectrochemistry System for Sustainable CO Methanation
Download Hi-Res ImageDownload to MS-PowerPointCite This:Environ. Sci. Technol.
Identification of UBE2C as hub gene in driving prostate cancer by integrated bioinformatics analysis
Loading metrics Open Access Peer-reviewed Research Article Yan Wang, Jili Wang, Qiusu Tang, Guoping Ren Yan Wang, Jili Wang, Qiusu Tang, Guoping Ren Published: February 25, 2021 https://doi.org/10.1371/journal.pone.0247827 Figures Abstract Background The aim of this study was to identify novel genes in promoting primary prostate cancer (PCa) progression and to explore its role in the prognosis of prostate cancer.
Enhancing colorimetric loop-mediated isothermal amplification speed and sensitivity with guanidine chloride
Loop-mediated isothermal amplification (LAMP) was developed as a simple nucleic acid amplification technique that reliably detects target sequence at a single reaction temperature without the need for sophisticated thermal cycling equipment [1]. Advances in various detection technologies have helped establish LAMP as a useful and versatile tool for molecular diagnostics [2].
ME1 promotes basal-like breast cancer progression and associates with poor prognosis
ME1 is upregulated in BLBC subtype We recently reported several metabolic genes aldo-keto reductase 1 member B1 (AKR1B1), fructose-1,6-biphosphatase (FBP1) and urine diphosphate–galactose ceramide galactosyltransferase (UGT8) that contributed to BLBC progression14,20,21.
Physical interaction between human ribonucleotide reductase large subunit and thioredoxin increases colorectal cancer malignancy
Ribonucleotide reductase (RR) is the rate-limiting enzyme in DNA synthesis, catalyzing the reduction of ribonucleotides to deoxyribonucleotides. During each enzymatic turnover, reduction of the active site disulfide in the catalytic large subunit is performed by a pair of shuttle cysteine residues in its C-terminal tail. Thioredoxin (Trx) and glutaredoxin (Grx) are ubiquitous redox proteins, catalyzing thiol-disulfide exchange reactions.
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