Guoxing You

Abstract Drug-resistant bacterium-infected wounds pose a serious clinical challenge, underscoring the need for therapeutic materials that respond to dynamic healing stages. Herein, we report a sequential multimodal platform embedding a self-adaptive IrPtCu nanozyme into a madecassoside-enriched hyaluronic acid hydrogel (HIPCM) for rapid bacterial eradication and accelerated wound healing.

We downloaded the mRNA expression, clinical, and tumor mutation data of the esophageal cancer dataset from the University Of California Santa Cruz. The ESCA dataset contained 162 human esophageal tissue samples, of which 151 were cancerous (included 71 adenocarcinoma samples, 79 squamous cell neoplasms samples, and one serous neoplasm sample) and 11 were normal. Tumor samples were randomly assigned to the training and test sets in a 1:1 ratio. Table 1 show the clinical data of the samples.

Qian Meng,1,* Xiaowei Yang,1,* Zhongcheng Liu,2 Guoxing You,3 Wanyi Chen,3 Bing Zhao,1 Huizi Zhu,4 Liang Xu,1 Yan Zhou,1 Xiang Liu,1 Chunjuan Zhai,5 Rong Wang,1 Lian Zhao,3 Jing Sun1 1Department of Nephrology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, People’s Republic of China; 2Department of Cardiovascular, The North City Hospital of Jinan, Jinan, Shandong, 250031, People’s Republic of China; 3Academy of Military Medical...