Gurumoorthy Krishnamoorthy on Muck Rack

Gurumoorthy Krishnamoorthy

As seen in: Color Research & Application, Nature, Cell Reports
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Articles

A secondary metabolite of Limosilactobacillus reuteri R2lc drives strain-specific pathology in a spontaneous mouse model of multiple sclerosis

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By Dale Archer, Maria Elisa Perez-Munoz, Stephanie L. Tollenaar, Simona M. Veniamin, Naomi Hotte, Christopher Cheng, Jee-Hwan Oh, Susan Muncner, Daniel R. Barreda, Gurumoorthy Krishnamoorthy, Christopher Power, Jan-Peter van Pijkeren, Jens Walter, Kristoff Nieves, Lilian Morceli
| Cell Reports Verified
Keywords Limosilactobacilus reuteri industrialization multiple sclerosis experimental autoimmune encephalomyelitis autoimmunity aryl hydrocarbon recepteor (AhR) signaling polyketide synthase (pks) cluster strain-specificity secondary metabolite probiotics Research topic(s) CP: Microbiology Introduction Disease progression in multiple sclerosis (MS), a neurodegenerative autoimmune disease, is driven in part by macrophages and autoreactive T cells (particularly CD8+ T cells and CD4+ T helper 1...
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A novel CD4 knockout mouse strain with a spontaneous frameshift mutation in the CD4 locus

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By Gurumoorthy Krishnamoorthy, Mathangi Janakiraman, Shin-Young Na
| PLOS
Loading metrics Open Access Peer-reviewed Research Article Mathangi Janakiraman, Shin-Young Na, Gurumoorthy Krishnamoorthy Mathangi Janakiraman, Shin-Young Na, Gurumoorthy Krishnamoorthy Published: April 6, 2022 https://doi.org/10.1371/journal.pone.0266589 Abstract T cells express co-receptors CD4 and CD8, which are involved in the recognition of antigen presented to T cell receptors.
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Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms

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By Arno Meiler, Gurumoorthy Krishnamoorthy, Francesca Palandri, Robert Zeiser
| Nature Verified
Abstract Janus kinases (JAKs) mediate responses to cytokines, hormones and growth factors in haematopoietic cells1,2. The JAK gene JAK2 is frequently mutated in the ageing haematopoietic system3,4 and in haematopoietic cancers5. JAK2 mutations constitutively activate downstream signalling and are drivers of myeloproliferative neoplasm (MPN).
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