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Gusu College

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Articles

LGR6 couples maresin 1 signaling to glycolytic flux and protein lactylation for the rescue of diabetic cardiomyopathy

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By Bin Feng, Chao Chen, Gusu College
| Wiley Online Library Verified
INTRODUCTION Diabetic cardiomyopathy (DbCM) constitutes a distinct pathological entity defined by myocardial structural and functional abnormalities that arise independently of coronary artery disease and hypertension, contributing significantly to the excess mortality associated with diabetes mellitus.1-3 Pathophysiologically, the diabetic heart is characterized by profound metabolic disturbances, primarily metabolic inflexibility marked by an overreliance on fatty acid oxidation and a...
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