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Articles by Guy Gorochov
Affinity-matured B cell responses neutralizing type-I interferons underlie severe viral infections
Keywords type-I interferon B cells antibodies COVID-19 autoimmunity Sars-CoV-2 affinity maturation memory B cells severe viral infections Get full text access Log in, subscribe or purchase for full access. References 1. Crow, Y.J. ∙ Casanova, J.-L. Human life within a narrow range: The lethal ups and downs of type I interferons Sci. Immunol. 2024; 9, eadm8185 2. Bastard, P. ∙ Gervais, A. ∙ Le Voyer, T. ...
Disruption of IgA-mediated aggregation at weaning favors mucus encroachment by commensal bacteria - npj Biofilms and Microbiomes
Abstract Disruption of the gut mucus barrier is critical in the development of infectious or chronic inflammatory diseases. The suckling-to-weaning transition is pivotal to the barrier maturation and is associated with a high incidence of gastrointestinal infections. Using a novel microfluidic device, we investigated the penetration and organizational properties of motile Escherichia coli bacteria at the interface of purified intestinal mucus from piglets before and after weaning.
EBV and the making of lupus
Abstract Epstein-Barr virus–mediated B cell reprogramming may initiate systemic lupus erythematosus (Younis et al., this issue). Access the full article View all access options to continue reading this article. REFERENCES AND NOTES 1 S. Younis, S. I. Moutusy, S. Rasouli, S. Jahanbani, M. Pandit, X. Wu, S. Acharya, O. Sharpe, T. U. Wijeratne, M. L. Harris, E. Y. Yang, Y. Chaichian, S. Parsafar, M. C. Baker, J. B. Harley, E. Meffre, L. Steinman, A. Marshak-Rothstein, J. A. James, O. M. Martinez, P. J. Utz, D. E. Orange, T. V.
Serum and Salivary IgG and IgA Response After COVID-19 Messenger RNA Vaccination
Key Points Question Can intramuscularly administered messenger RNA vaccines induce mucosal immunity? Findings In this cohort study of 427 vaccinated individuals, a modest increase in spike-specific IgA levels in saliva of SARS-CoV-2–naive individuals having received the Moderna or Pfizer-BioNTech messenger RNA vaccines was observed using ultrasensitive digital enzyme-linked immunosorbent assay.
A comparison of Sars-Cov-2 vaccine platforms: the CoviCompare project - Nature Medicine
To the Editor — Since December 2019, the COVID-19 pandemic has spread from China across the world. As the pandemic continues, 19 vaccines using different technologies have been authorized and are now being used for large vaccination programs worldwide. These vaccines are based on different vaccine platforms (mRNA, recombinant viruses, adjuvanted recombinant proteins and inactivated viruses) that have never been compared in terms of immunogenicity using the same standardized immunological readouts.
Considering Personalized Interferon Beta Therapy for COVID-19
Letter to the Editor Karim Dorgham, Avidan U. Neumann, Maxens Decavele, Charles-Edouard Luyt, Hans Yssel, Guy Gorochov DOI: 10.1128/AAC.00065-21 Log in using your username and password Username * Password * Forgot your user name or password? Log in through your institution You may be able to gain access using your login credentials for your institution. Contact your library if you do not have a username and password.
Mucosal Immunity in COVID-19: A Neglected but Critical Aspect of SARS-CoV-2 Infection
Introduction Although the COVID-19 pandemic has been ongoing now for several months, very little attention has been given to mucosal immunity in SARS-CoV-2 infection. Yet this virus primarily infects the mucosal surfaces of the respiratory tract (and possibly also the digestive tract) at least until advanced stages of the disease when viral RNA may become detectable in the circulation (1).
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