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Guy Sella on Muck Rack

Guy Sella

As seen in: Nature, PLOS, PLOS Biology, PNAS, Le Journal du Net, BioRxiv, The American Journal of Human Genetics, Globes, eLife, Genetics
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Articles

Adaptation: by giant leaps or many tiny steps?

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By William R. Milligan, Guy Sella
| Nature Verified
Despite more than a century of research, we still lack a general understanding of the genetic basis of adaptation. We argue that reframing this question around the genetic and ecological properties of the traits under selection may chart a way forward.
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Principled measures and estimates of trait polygenicity

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By Luke O’Connor, Guy Sella
| The American Journal of Human Genetics Verified
Keywords polygenicity genetic architecture genome-wide association studies Get full text access Log in, subscribe or purchase for full access. References 1. Jobling, M. ∙ Hollox, E. ∙ Hurles, M. ... Human Evolutionary Genetics Garland Science, Taylor & Francis, 2014 2. Lango Allen, H. ∙ Estrada, K. ∙ Lettre, G. ... Hundreds of variants clustered in genomic loci and biological pathways affect human height Nature. 2010; 467:832-838 3. International Schizophrenia Consortium ∙ Purcell, S.M. ∙ Wray, N.R. ...
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Gene regulatory network structure informs the distribution of perturbation effects

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By Matthew Aguirre, Jeffrey P. Spence, Guy Sella, Jonathan Pritchard
| PLOS
Citation: Aguirre M, Spence JP, Sella G, Pritchard JK (2025) Gene regulatory network structure informs the distribution of perturbation effects. PLoS Comput Biol 21(9): e1013387. https://doi.org/10.1371/journal.pcbi.1013387 Editor: Sushmita Roy, University of Wisconsin, Madison, UNITED STATES OF AMERICA Received: October 23, 2024; Accepted: August 3, 2025; Published: September 2, 2025 Copyright: © 2025 Aguirre et al.
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