Gyesoon Yoon

Abstract Valosin-containing protein (VCP)/p97, an AAA+ ATPase critical for maintaining proteostasis, emerges as a promising target for cancer therapy. This study reveals that targeting VCP selectively eliminates breast cancer cells while sparing non-transformed cells by inducing paraptosis, a non-apoptotic cell death mechanism characterized by endoplasmic reticulum and mitochondria dilation. Intriguingly, oncogenic HRas sensitizes non-transformed cells to VCP inhibition-mediated paraptosis.

Research Paper Volume 15, Issue 24 pp 14591—14606 1 Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 16499, Korea 2 Inflamm-aging Translational Research Center, Ajou University Medical Center, Suwon 16499, Korea 3 Department of Biomedical Sciences, Graduate School of Ajou University, Suwon 16499, Korea https://doi.org/10.18632/aging.205420 How to Cite Cite this Article Select the format you require from the list below Click to copy this citation from...