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Gyu Lee

As seen in: Nature, Wiley Online Library, MDPI, The American Journal of Human Genetics

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Articles

De novo design of miniproteins targeting GPCRs

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By Edin Muratspahić, David Feldman, Xiangli Qu, Paula Rivera-Sánchez, Jan Hendrik Voss, Emil P. T. Hertz, Mads Jeppesen, Federica Dimitri, Kensuke Sakamoto, Amrita Nallathambi, Jianjun Cao, Brian P. Cary, Matthew Belousoff, Peter Keov, Phuc Trinh, Qingchao Chen, Yue Ren, Sudha Mishra, Annu Dalal, Ramanuj Banerjee, Manisankar Ganguly, Isaac Sappington, Thomas Schlichthaerle, Jason Zhang, Arvind Pillai, Brian Coventry, Ljubica Mihaljevic, Magnus Krogstad Bauer, Susana Torres, Amir Motmaen, Gyu Lee, Long Tran, Xinru Wang, Inna Goreshnik, Dionne Vafeados, Justin E. Svendsen, Parisa Hosseinzadeh, Matthäus Brandt, Yann Waltenspühl, Kristine Deibler, Anja Bennett, Jendrik Schöppe, Xiaoli Yan, William Cao, Ayodeji A. Asuni, Justin G. English, Lance Stewart, Lauren Kay Halloran, Jamie B. Spangler, André Lieber, Arun Shukla, Patrick Sexton, Bryan Roth, Brian Krumm, Denise Wootten, Christopher Tate, Christoffer Norn, David Baker, Ana-Maria Bratovianu, Pia Peceli, Justyn Fine, Shachie Sinha, Karthik Varappalayam Karuppusamy, Nicolai Lindegaard, Lukas Deweid, Tiantang Dong, Luke Oostdyk, Lakshmi Anantharaman, Johan J. Weisser, Jesper Frank Bastlund, Christoffer Bundgaard
| Nature Verified
Abstract G protein-coupled receptors (GPCRs) play key roles in physiology and are central targets for drug discovery and development1,2, but the design of protein agonists and antagonists has been challenging as GPCRs are integral membrane proteins and conformationally dynamic3–6. Here we describe computational de novo design methods and a high-throughput “receptor diversion” microscopy-based screen for generating GPCR binding miniproteins with high affinity, potency and selectivity.
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Small-molecule binding and sensing with a designed protein family

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By Gyu Lee, Samuel Pellock, Christoffer Norn, Doug Tischer, Justas Dauparas, Ivan Anishchenko, Alex Kang, Asim K. Bera, Hannah Nguyen Verified, Banumathi Sankaran, Inna Goreshnik, Dionne Vafeados, Nicole Roullier, Hannah Han, Brian Coventry, Hugh K. Haddox, David R. Liu, Andy Hsien-Wei Yeh, David Baker, Jaron A. M. Mercer, Evans Brackenbrough
| Nature Verified
Abstract The de novo design of small-molecule–binding proteins holds great promise as a potential tool to develop sensors on-demand for arbitrary small molecules. Here we combine deep learning and physics-based methods to generate a family of proteins with diverse and designable pocket geometries, which we employ to computationally design binders for six small-molecule targets.
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Bi-allelic variants in NRDC cause a neurodevelopmental disorder characterized by neonatal lethality, microcephaly, and brain abnormalities

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By Davut Pehlivan, Reza Maroofian, François Lecoquierre, Aisha Al Shamsi, Gyu Lee, Osman Yesilbas, Preston Taylor, Matthew Mcdougal, Vahid Bahrambeigi, Juan Ramirez, Juan Ramírez, khalid salih, Heba Morsy, Haytham Hussien, Tarek Omar, Ibrahim M. Abdelrazek, Dana Marafi, Tugba Kalayci, Eric Verspyck, Jawid Fatih, Tadahiro Mitani, Gulsen Akay, Daniel G. Calame, Wendy Chung, Henry Houlden, James R. Lupski, Adel Shalata, Wan Hee Yoon, Abigail Sandoval, Omid Aryani, Chadi Al Alam, Anne Claire Brehin, Jubran Abu Rahma, Jawabreh Kassem Talbeya, Husein Dabbah, Toktam Moosavian, Anne-Marie Guerrot
| The American Journal of Human Genetics Verified
Keywords NRDC NRD1 neurodevelopmental disorder lethality microcephaly mitochondria Introduction Nardilysin (NRDC, also known as NRD1) belongs to the zinc-metalloendopeptidase family.
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