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Jacob Merle Gershon on Muck Rack

Jacob Merle Gershon

As seen in: Nature, BioRxiv
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Articles

De novo design of cysteine proteases

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By Hojae Choi, Magnus S. Bauer, Brian Coventry, Preetham Venkatesh, Anqi Chen, Donghyo Kim, Asim K. Bera, Alex Kang, Hannah Nguyen Verified, Shayan Sadre, Justin Decarreau, Emily Joyce, Tuscan Thompson, Kieran Didi, Lars L. Schaaf, Jacob Merle Gershon, Gyu Lee, Donald Hilvert, Samuel Pellock, David Baker, Bhanumathi Shankaran, Gabriel Greenstein, Alexander F. Shida, David Baker
| Nature Verified
Abstract Despite advances in de novo enzyme design, success has been largely limited to low-energy-barrier model reactions. Amide bonds such as those linking amino acids along the peptide backbone are stable for hundreds of years in neutral aqueous solution because of the high energy barrier to hydrolysis1.
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Joint Generation of Protein Sequence and Structure with RoseTTAFold Sequence Space Diffusion

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By Samuel J. Hendel, Sidney Lyayuga Lisanza, Jacob Merle Gershon, Lucas Arnoldt
| BioRxiv
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