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Haiying Zeng

As seen in: Nature, Royal Society of Chemistry
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Articles

Activation of Nerve Growth Factor signaling limits the response to lenvatinib in hepatocellular carcinoma

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By Minghao Xu, Yimin Zheng, Longtao Zhao, Siwei Wang, Junbo Chen, Aying Ma, Bugang Liang, Yilan Huang, Haihan Xu, YUE WANG, Haiying Zeng, Chao Gao, Jiabin Cai, Aiwu Ke, Jia Fan, Zhongchi Fu, Yingjie Ai
| Nature Verified
Abstract Resistance to lenvatinib remains a major barrier in the treatment of advanced hepatocellular carcinoma (HCC), underscoring the urgent need to elucidate the underlying mechanisms and identify actionable therapeutic targets. In this study, we identified a neurosecretory factor derived from HCC cells, Nerve Growth Factor (NGF), as a critical mediator of lenvatinib resistance.
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