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Articles by Haiyu Chen
USP28 potentiates endothelial necroptosis via deubiquitinating NMMHC IIA in septic male mice
Abstract Endothelial dysfunction contributes to multi-organ injury in sepsis, but the underlying mechanisms remain incompletely understood. Here we show that endothelial ubiquitin-specific protease 28 (USP28) is increased in patients with sepsis and in male mice in a murine polymicrobial sepsis model. Mechanistically, USP28 stabilizes non-muscle myosin heavy chain IIA (NMMHC IIA) by removing K48-linked ubiquitination at K1413.
Ginsenoside Ra1 alleviates endothelial barrier dysfunction and multi-organ injury in experimental sepsis via NMMHC IIA inhibition
ALT alanine aminotransferase Bim Bcl-2-interacting mediator of cell death BUN blood urea nitrogen CETSA cellular thermal shift assay CLP caecal ligation and puncture CRP C-reactive protein Dex dexamethasone EB Evans blue ECs endothelial cells FOXO3a forkhead box O3a H&E haematoxylin and eosin HUVECs human umbilical vein endothelial cells IFNAR1 interferon alpha and beta receptor subunit 1 KEGG Kyoto Encyclopaedia of Genes and Genomes MST microscale thermophoresis MYH9 myosin heavy chain 9...
KRAS G12D inhibition reprograms the tumor-induced immunosuppressive environment and enhances NK cell–mediated antitumor immunity
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract KRASG12D mutation drives oncogenic progression and creates an immunosuppressive microenvironment in cancers like pancreatic ductal adenocarcinoma and colorectal cancer.
By Rui Yang, Ying Yuan, Amaia Ochandorena-Saa, Tuo Hu, Taiwei Mo, Lin Wang, Qiuqing Ke, Liangjie Chi, Hongyuan Chen, Chao Xu, Chenshen Huang, Aiping Lin, Shaoxin Cai, Haiyu Chen, Wenyu Wang, Longyang Jin, Haoyun Liu, Chuanyuan Liu, Abudumaimaitijiang Tuersun, Yan Zheng, Zuwei Wang, Shi Chen, Junzhang Zhao, Yimamu Baihetiyaer, Abuduhalike Abulimiti
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The effect of aromatherapy applied to pregnant women on sleep quality and fatigue level: A randomized clinical trial
Although pregnancy is a natural process, it causes significant anatomical, physiological, biochemical, and psychological changes in the maternal body.1,2 Due to these changes, pregnant women experience various physical complaints, including sleep problems and fatigue.3,4 Sleep is defined as a state of unconsciousness in which a person can be awakened by sensory or other stimuli such as sound and light.
Research on Comprehensive Vehicle Information Detection Technology Based on Single-Point Laser Ranging
1. Introduction In recent years, the continuous development of Intelligent Transportation Systems (ITSs) has placed higher demands on the traffic perception capabilities of smart roads, especially in terms of real-time performance, accuracy, and comprehensive sensing. However, traditional vehicle detection technologies are limited by their detection principles and data collection ranges, making it difficult to achieve comprehensive traffic condition awareness based on bayonet detection methods.
Characterisation of ginsenosides composition in processed American ginseng products using UPLC-MS coupled with chemometric analysis
Advanced search Natural Product Research Formerly Natural Product Letters Latest Articles Submit an article Journal homepage Full Article Figures & data References Supplemental Citations Metrics Reprints & Permissions Read this article /doi/full/10.1080/14786419.2024.2431127?needAccess=true Abstract American ginseng(Panax quinquefolius L.), a traditional herbal extensively utilised in China, exhibits both medicinal and food properties.
Safe Trajectory Planning for Incremental Robots Based on a Spatiotemporal Variable-Step-Size A* Algorithm
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Predicting Highway Risk Event with Trajectory Data: A Joint Approach of Traffic Flow and Vehicle Kinematics
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Research on an Adaptive Method for the Angle Calibration of Roadside LiDAR Point Clouds
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by , , , , and * School of Intelligent Systems Engineering, Sun Yat-sen University, Shenzhen 518107, China * Author to whom correspondence should be addressed.
Cadmium‐induced pyroptosis is mediated by PERK/TXNIP/NLRP3 signaling in SH‐SY5Y cells
Filename Description tox23861-sup-0001-Supinfo.pdfPDF document, 223.5 KB DATA S1. Supporting Information. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Study on the Solubility of Industrial Lignin in Choline Chloride-Based Deep Eutectic Solvents
Open AccessArticle by 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 2 and 1,2,* 1 State Key Laboratory Base of Eco-Chemical Engineering, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China 2 Guangxi Key Laboratory of Clean Pulp and Papermaking and Pollution Control, College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China * Author to whom correspondence should be addressed.
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