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Articles by Hamida Hammad
Innate type 2 lymphocytes trigger an inflammatory switch in alveolar macrophages
Keywords asthma type 2 immunity alveolar macrophage macrophage niche PPARγ IRF4 ILC2 multinucleated giant cell chemokines alternatively activated macrophages Get full text access Log in, subscribe or purchase for full access. References 1. Guilliams, M. ∙ Thierry, G.R. ∙ Bonnardel, J. ... Establishment and Maintenance of the Macrophage Niche Immunity. 2020; 52:434-451 2. Hashimoto, D. ∙ Chow, A. ∙ Noizat, C. ...
The immunology of asthma - Nature Immunology
Abstract Asthma is a chronic inflammatory disease of the airways characterized by variable airway obstruction. In some patients with severe disease there are frequent disease flares, and some individuals develop irreversible airway obstruction. The immune system has a predominant effect on many aspects of the disease.
CAR T cells put the brakes on asthma - Nature Immunology
CAR T cell technology is being extended beyond the treatment of cancer. New data show that it might also treat allergic asthma, with a single infusion sufficient to prevent pathology for over a year in mice.
Emerging Paradigms in Type 2 Immunity
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IFN-γ(g)uarding the niche-Keeping ILC2 in check
The causal signals and the relevance of group 2 innate lymphoid cell (ILC2) dynamic redistribution during inflammation remain unknown. In this issue of Immunity, Cautivo et al. show that type 2 immunity drives ILC2 accumulation at non-adventitial “parenchymal” sites, allowing balanced responses in inflamed tissues.
The basic immunology of asthma
(Cell 184, 1469–1485; March 18, 2021) We have identified two errors in the originally published review. The legends of Figure 3 and Figure 5 did not match the figure content. They have now been swapped to allow the correct description of each figure. In addition, the eosinophil symbol in Figure 5 was too close to the one of neutrophils in Figure 6. Figure 5 has now been corrected online. The authors apologize for any confusion these errors may have caused.
The basic immunology of asthma
Agache I. Song Y. Rocha C. Beltran J. Posso M. Steiner C. Alonso-Coello P. Akdis C. Akdis M. Canonica G.W. et al. Efficacy and safety of treatment with dupilumab for severe asthma: A systematic review of the EAACI guidelines-Recommendations on the use of biologicals in severe asthma. Allergy. 2020; 75: 1058-1068 Al-Ramli W. Préfontaine D. Chouiali F. Martin J.G. Olivenstein R. Lemière C. Hamid Q. T(H)17-associated cytokines (IL-17A and IL-17F) in severe asthma. J. Allergy Clin. Immunol.
Wnt and Hippo pathways in regulatory T cells: a NOTCH above in asthma
The activation of the Notch4–Wnt–GDF15 axis in induced regulatory T (Treg cells) dampens their immunoregulatory function and turns them into TH2 and TH17 cytokine producers, allowing them to maintain ongoing allergic asthma. Fig. 1: Notch4+ Treg cells contribute to TH2 immunity following exposure to allergens and air pollutants. Debbie Maizels/Springer Nature References 1. Bailis, W. et al. Immunity 39, 148–159 (2013). CAS Article Google Scholar 2. Harb, H. et al. Nat. Immunol.
Rbm7 in Structural Cells: A NEAT Way to Control Fibrosis
The initial molecular events and the cell type(s) responsible for the development of fibrosis are unclear. Fukushima, Satoh, et al. find that increased expression of the nuclear exosome targeting complex component Rbm7 in lung epithelial cells promotes the degradation of the long non-coding RNA NEAT1, impairs DNA repair, and triggers apoptosis. Dying epithelial cells release chemokines that recruit atypical monocytes, which drive tissue fibrosis.
The Cytokines of Asthma
Asthma is a chronic inflammatory airway disease associated with type 2 cytokines interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus overproduction, bronchial hyperresponsiveness (BHR), and immunogloubulin E (IgE) synthesis. However, only half of asthma patients exhibit signs of an exacerbated Type 2 response. “Type 2-low” asthma has different immune features: airway neutrophilia, obesity-related systemic inflammation, or in some cases, few signs of immune activation.
Professional and ‘Amateur’ Antigen-Presenting Cells In Type 2 Immunity
Mukai K. et al. IgE and mast cells in host defense against parasites and venoms. Semin. Immunopathol. 2016; 38: 581-603 Palm N.W. et al. Allergic host defences. Nature. 2012; 484: 465-472 Lambrecht B.N. Hammad H. The immunology of the allergy epidemic and the hygiene hypothesis. Nat. Immunol. 2017; 18: 1076-1083 Paul W.E. What determines Th2 differentiation, in vitro and in vivo?. Immunol. Cell Biol. 2010; 88: 236-239 Kambayashi T.
The emerging role of ADAM metalloproteinases in immunity
1.Wolfsberg, T. G. et al. The precursor region of a protein active in sperm-egg fusion contains a metalloprotease and a disintegrin domain: structural, functional, and evolutionary implications. Proc. Natl Acad. Sci. USA 90, 10783–10787 (1993).2.Wolfsberg, T. G., Primakoff, P., Myles, D. G. & White, J. M. ADAM, a novel family of membrane proteins containing a disintegrin and metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions. J. Cell Biol.
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