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Anoxia-induced hippocampal LTP is regeneratively produced by glutamate and nitric oxide from the neuro-glial-endothelial axis
Highlights • Glutamate elevated by anoxia boosts evoked glutamate release via ·NO synthesis • NMDA receptor activation induces ·NO release from neurons and vascular endothelia • Glutamate activates endothelial ·NO synthesis via astrocytic Ca2+ and D-serine • Anoxia-induced sustained glutamate release blocks memory-associated stimulation-induced LTP Summary Transient anoxia causes amnesia and neuronal death.
Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer’s disease synapse model
Decision letter after peer review: Thank you for submitting your article "Microtubule assembly by soluble tau impairs vesicle endocytosis and excitatory neurotransmission via dynamin sequestration in Alzheimer's disease synapse model" for consideration by eLife. Your article has been reviewed by 2 peer reviewers, and the evaluation has been overseen by a Reviewing Editor and Suzanne Pfeffer as the Senior Editor. The reviewers have opted to remain anonymous.
Frequency-Dependent Block of Excitatory Neurotransmission by Isoflurane via Dual Presynaptic Mechanisms
Research Articles, Cellular/Molecular Han-Ying Wang, Kohgaku Eguchi, Takayuki Yamashita and Tomoyuki Takahashi Journal of Neuroscience 20 May 2020, 40 (21) 4103-4115; DOI: https://doi.org/10.1523/JNEUROSCI.2946-19.2020 Abstract Volatile anesthetics are widely used for surgery, but neuronal mechanisms of anesthesia remain unidentified.
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