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Hangchang Shen on Muck Rack

Hangchang Shen

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Articles

Fusobacterium nucleatum drives colorectal cancer progression through the circPTBP 3/ miR-760 / PUM1 axis

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By Qianqian Liu, Linna Fu, Yingxuan Chen, Chunmin Li, Hangchang Shen, Tianhui Zou
| Nature Verified
Abstract Circular RNAs (circRNAs) perform critical functions in cancer biology, commonly serving as microRNA (miRNA) sponges to modulate gene expression. Nevertheless, their participation in gut microbiota-driven colorectal cancer (CRC) has yet to be substantially investigated. Fusobacterium nucleatum (F. nucleatum), a well-recognized oncogenic bacterium in the human gut, has been implicated in CRC development, but the underlying mechanisms are not fully defined.
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