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Yingxuan Chen

As seen in: Nature, Royal Society of Chemistry, Cell Press, International Journal of Radiation Oncology*Biology*Physics
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Articles

Fusobacterium nucleatum drives colorectal cancer progression through the circPTBP 3/ miR-760 / PUM1 axis

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By Qianqian Liu, Linna Fu, Yingxuan Chen, Chunmin Li, Hangchang Shen, Tianhui Zou
| Nature Verified
Abstract Circular RNAs (circRNAs) perform critical functions in cancer biology, commonly serving as microRNA (miRNA) sponges to modulate gene expression. Nevertheless, their participation in gut microbiota-driven colorectal cancer (CRC) has yet to be substantially investigated. Fusobacterium nucleatum (F. nucleatum), a well-recognized oncogenic bacterium in the human gut, has been implicated in CRC development, but the underlying mechanisms are not fully defined.
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Candida albicans synergizes with Fusobacterium nucleatum in colorectal cancer progression via the Flo9-RadD interaction

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By Jialu Li, Chenyi Zhang, Xinhua Huang, Hongxiang Sun, Hongzhi Liu, Lu Zhang, Ningbo Wu, Yuanhong Xie, Jingjing Qi, Xiaoxu Leng, Yun Cui, Ziran Kang, Zhuolei Kou, Ning-Ning Liu, Pengfei Lan, Beilei Xuan, Dengfeng Cao, Guo-Xiang Cai, Yingxuan Chen, Jianfeng Chen, Zhaoyuan Liu, Florent Ginhoux, Changbin Chen, Bing Su, Jing-Yuan Fang
| Cell Press Verified
Keywords Fusobacterium nucleatum Candida albicans colorectal cancer microbiota fungi Flo9 RadD Get full text access Log in, subscribe or purchase for full access. References 1. Helmink, B.A. ∙ Khan, M.A.W. ∙ Hermann, A. ... The microbiome, cancer, and cancer therapy Nat. Med. 2019; 25:377-388 2. Sepich-Poore, G.D. ∙ Zitvogel, L. ∙ Straussman, R. ... The microbiome and human cancer Science. 2021; 371, eabc4552 3. Garrett, W.S. The gut microbiota and colon cancer Science. 2019; 364:1133-1135 4. Hanahan, D.
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Systematic evaluation of the impact of lung segmentation methods on 4DCT-ventilation imaging using a large patient database

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By Yingxuan Chen, Thomas Jefferson, Paul Jacobs, Soroush Heidari Pahlavian
| International Journal of Radiation Oncology*Biology*Physics Verified
ABSTRACT A novel form of lung functional imaging applied for functional avoidance radiotherapy has been developed that uses 4DCT data and image processing techniques to calculate lung ventilation (4DCT-ventilation). Lung segmentation is a common step to define a region of interest for 4DCT ventilation generation. The purpose of this study was to quantitatively evaluate the sensitivity of 4DCT-ventilation imaging using different lung segmentation methods.
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