Keywords OTULIN LUBAC PIM-PUB interaction LUBAC autoubiquitination Met1-Ub TNF signaling NF-κB activation cell death inflammation immune pathology Introduction Inflammation is an essential protective mechanism during infection but can cause tissue damage and fatality when dysregulated.1,2 Tumor necrosis factor (TNF) promotes inflammation through activation of mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) signaling and indirectly by inducing cell death.1,3 The...
