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Hannah Barman

As seen in: Wiley Online Library, ONCOLOGY journal
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Articles

48 Prevalence of “HER2 Ultra-Low” Among Advanced Breast Cancer Patients With Historical IHC0 Status

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By Hannah Barman, Anushree Iyengar, Nivedita Rangarajan, Sue-Ann Woo
| ONCOLOGY journal Verified
Background This study aimed to assess the prevalence of “HER2 Ultra-Low” (faint membrane staining in >0 but ≤10% of tumor cells) expression based on re-scored HER2 IHC0 biopsy slides. Materials and Methods From all 3 US Mayo Clinic campuses, a total of 300 patients with advanced breast cancer (stages III-IV), and clinically documented HER2 IHC0 status between January 2017 and January 2023, were identified.
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Liver disease progression in patients with alpha‐1 antitrypsin deficiency and protease inhibitor ZZ genotype with or without lung disease

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By Tiffany Wu Verified, May Hagiwara, Esteban Gnass, Hannah Barman
| Wiley Online Library Verified
1 INTRODUCTION Alpha-1 antitrypsin deficiency (AATD) is a rare genetic condition associated with liver and/or lung disease.1 AATD is caused by mutations in SERPINA1, which encodes the serine protease inhibitor (Pi) alpha-1 antitrypsin (AAT).2 The Z allele carries the most common severe disease-causing variant, encoding Glu342Lys in AAT2; the Z-form of AAT (Z-AAT) is strongly associated with liver disease.3 In clinical practice, 96% of AATD-related diseases occur in individuals with a...
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