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Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism
Keywords DLAT hepatocellular carcinoma leucine catabolism acetylation LNP-mRNA Introduction According to recent statistics, hepatocellular carcinoma (HCC) has shown remarkably increased morbidity and mortality in populations worldwide.1,2 The role of metabolic reprogramming in the progression of liver cancer is continuously being clarified.
Reduced hepatic bradykinin degradation accounts for cold-induced BAT thermogenesis and WAT browning in male mice - Nature Communications
Abstract An important role for liver in the regulation of adipose tissue thermogenesis upon cold exposure has been suggested; however, the underlying mechanisms remain incompletely defined. Here, we identify elevated serum bradykinin levels in response to acute cold exposure in male mice. A bolus of anti-bradykinin antibodies reduces body temperature during acute cold exposure, whereas bradykinin has the opposite effect.
A fifty percent leucine-restricted diet reduces fat mass and improves glucose regulation
Abstract Background Leucine deprivation modulates the dietary amino acid composition, reducing the fat content and improving the glucose tolerance, thus protecting the organism against obesity. However, a complete deprivation of leucine can lead to an extremely rapid fat loss in mice, accompanied by prolonged adverse effects such as weakness and mental fatigue.
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