Skip To Main Content
Yingjie Xu on Muck Rack

Yingjie Xu

As seen in: AIChE Journal, Nature, Wiley Online Library, ScienceDirect, Frontiers, MDPI, Taylor & Francis Online, ACS Publications, Arthritis Research & Therapy, BMC Cancer and
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Yingjie

Contact Yingjie, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

Overexpression of KRAS-Q25A mutant with enhanced GTPase activity inhibits the progression of KRAS-G12D colorectal cancer

|
By Juncheng Su, Yingjie Xu, Zheng Wang, Xuehan Yan
| Nature Verified
Abstract Oncogenic KRAS mutations occur in approximately 40% of colorectal cancer (CRC) cases and correlate with poor prognosis. While restoring GTP hydrolysis in KRAS-mutant tumors represents a promising therapeutic strategy, its mechanistic basis remains unclear. KRASQ25A mutant exhibits enhanced intrinsic GTPase activity, but its cellular impact is unknown. Here, we investigated the tumor-suppressive effects of KRASQ25A in KRASG12D-mutant CRC.
Open in Who Shared Issue with article?

Reproductive behaviors, genetic susceptibility and accelerated aging risk

|
By Jinghui Zhong, Deyan Kong, Yiran Dong, MingMing Yu, Pan Zhang, Yingjie Xu, Xinfeng Liu, Wen Sun, Genpei Luo
| Nature Verified
Abstract We examined the associations of reproductive behaviors and genetic susceptibility with aging indicators among female participants in the UK Biobank. Reproductive behaviors included the number of children ever born (NEB), age at first birth (AFB), age at last birth (ALB), and span of years of births (SYB). Aging indicators included frailty, PhenoAge acceleration, KDM-BA acceleration, and brain age difference (BrainAGE-diff).
Open in Who Shared Issue with article?

CD8 + T cell loss induces autoinflammation in inborn errors of cell death

|
By Jialin Dai, Taijie Jin, Gaixiu Su, Xu Han, Jun Wang, Chenlu Liu, Wenjie Zheng, Qiuye Zhang, Ranran Zhang, Hye Sun Kuehn, Jun Yang, Li Guo, Dan Zhang, Ming Li, Yingjie Xu, Tong Yue, Min Wen, Jia Zhu, Min Sun Kang, Jianming Lai, Feifei Wu, Shihao Wang, Jiahui Zhang, Ivona Aksentijevich, Sergio Rosenzweig, Pui Lee, Junying Yuan, Xiaomin Yu, Qing Zhou
| Nature Verified
Abstract Systemic autoinflammatory diseases (SAID) with inborn errors of cell death (IECD) are caused by overactivation of programmed cell death (PCD). However, the pathogenesis by which PCD leads to autoinflammation remains unclear. Here, we identified IECD patients carrying compound heterozygous RIPK1 variants K377E/R390G with autoinflammatory manifestations. Mechanistically, K377E and R390G mutations suppress NF-κB signaling and activate RIPK1 to promote cell death.
Open in Who Shared Issue with article?
See all 51 licensed articles (54 Total)