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Yingjie Xu on Muck Rack

Yingjie Xu

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Articles

Reproductive behaviors, genetic susceptibility and accelerated aging risk

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By Jinghui Zhong, Deyan Kong, Yiran Dong, MingMing Yu, Pan Zhang, Yingjie Xu, Xinfeng Liu, Wen Sun, Genpei Luo
| Nature Verified
Abstract We examined the associations of reproductive behaviors and genetic susceptibility with aging indicators among female participants in the UK Biobank. Reproductive behaviors included the number of children ever born (NEB), age at first birth (AFB), age at last birth (ALB), and span of years of births (SYB). Aging indicators included frailty, PhenoAge acceleration, KDM-BA acceleration, and brain age difference (BrainAGE-diff).
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CD8 + T cell loss induces autoinflammation in inborn errors of cell death

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By Jialin Dai, Taijie Jin, Gaixiu Su, Xu Han, Jun Wang, Chenlu Liu, Wenjie Zheng, Qiuye Zhang, Ranran Zhang, Hye Sun Kuehn, Jun Yang, Li Guo, Dan Zhang, Ming Li, Yingjie Xu, Tong Yue, Min Wen, Jia Zhu, Min Sun Kang, Jianming Lai, Feifei Wu, Shihao Wang, Jiahui Zhang, Ivona Aksentijevich, Sergio Rosenzweig, Pui Lee, Junying Yuan, Xiaomin Yu, Qing Zhou
| Nature Verified
Abstract Systemic autoinflammatory diseases (SAID) with inborn errors of cell death (IECD) are caused by overactivation of programmed cell death (PCD). However, the pathogenesis by which PCD leads to autoinflammation remains unclear. Here, we identified IECD patients carrying compound heterozygous RIPK1 variants K377E/R390G with autoinflammatory manifestations. Mechanistically, K377E and R390G mutations suppress NF-κB signaling and activate RIPK1 to promote cell death.
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Dynamic Updating Method of Course Content Based on Multiple Intelligent Agents Collaboration

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By Sheng Jie, Yingjie Xu, Xian Jiang, Mengfan Xiao
| Wiley Online Library Verified
Conflicts of Interest The authors declare no conflicts of interest. References 1, , , et al., “The Challenges of Evolving Technical Courses at Scale: Four Case Studies of Updating Large Data Science Courses,” in Proceedings of the Ninth ACM Conference on Learning@ Scale (ACM, 2022), 201–211. 2, , , , , and , “The Impact of Gamification on Learning Outcomes of Computer Science Majors,” ACM Transactions on Computing Education 20, no. 2 (2020): 1–25.
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