Hans-Heinrich Hoffmann

We then hypothesized that soluble factors contribute to the establishment of a neuroprotective state following footpad poly(I:C) administration. Both WNV footpad infection and poly(I:C) induced a range of pro-inflammatory serum cytokines as indicated by π-score, a metric combining fold change and statistical significance64 (Figure S5A). Analogous to our transcriptomic approach, we performed comparative analyses of serum cytokines following footpad administration of poly(I:C), LPS, or ODN1826.

Abstract Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)1. The rapid development of highly effective vaccines2,3 against SARS-CoV-2 has altered the trajectory of the pandemic, and antiviral therapeutics4 have further reduced the number of COVID-19 hospitalizations and deaths.