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Hanxiao Yin

As seen in: Nature
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Articles

USP21-mediated deubiquitylation stimulates NuMA recruitment to the cell cortex to promote mitotic spindle orientation

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By Mingzheng Hu, Huixian Ma, Jinqiong Wang, Lin Li, Difei Wang, Hanxiao Yin, Mulin Yang, Feifei Qi, Ying Shan, Huijie Zhao, Jinmin Gao, Dengwen Li, Min Liu, Jun L Zhou, Runa Wang, Zhenqi Yu
| Nature Verified
Abstract Proper orientation of the mitotic spindle is critical for a wide range of biological processes. However, the molecular mechanisms that regulate the formation of the spindle orientation machinery remain incompletely understood. In this study, we identify an essential role for ubiquitin-specific peptidase 21 (USP21)-mediated deubiquitylation in the control of spindle orientation.
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The parkin-γ-tubulin axis regulates epidermal homeostasis and is associated with the susceptibility to psoriasis - Cell Death & Differentiation

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By Yuanyuan Liu, Shaoze Yan, Jiaxuan Wang, Dan Dong, Shaodong Yan, Hanxiao Yin, Kai Liu, Min Liu, Hong liu, Dengwen Li, Jinmin Gao, Wei Xie, Jun L Zhou
| Nature Verified
Abstract Psoriasis is an inflammatory skin disease marked by excessive proliferation of keratinocytes, and there is accumulating evidence indicating its association with Parkinson’s disease (PD). However, the molecular link between these two diseases remains elusive. Herein, we identify a potential role for parkin, a PD-related E3 ubiquitin ligase, in the inhibition of psoriasis pathogenesis. The level of parkin is reduced in psoriatic skin both in clinical samples and in mouse models.
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HDAC6 deacetylates IDH1 to promote the homeostasis of hematopoietic stem and progenitor cells

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By jia yang, Haihe Laboratory, Yang Liu, Hanxiao Yin
| embopress.org
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