Haran Sivakumaran on Muck Rack

Haran Sivakumaran

As seen in: Nature, PLOS, Genome Biology, Molecular Cancer, medRxiv
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Articles

Suppressing recurrence in Sonic Hedgehog subgroup medulloblastoma using the OLIG2 inhibitor CT-179 - Nature Communications

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By Yuchen Li, Daniel S. Malawsky, Sho Oasa, Carolin Offenhauser, Stacey Edwards, Juliet D. French, Haran Sivakumaran, Lachlan Harris, Santosh Kesari, Gregory Stein, Terrance G. Johns, Marina Sokolsky-Papkov, Lars Terenius, Vladana Vukojevic, Timothy R. Gershon, Ulrich Baumgartner
| Nature
Abstract OLIG2-expressing tumor stem cells have been shown to drive recurrence in Sonic Hedgehog (SHH)-subgroup medulloblastoma (MB) and patients urgently need specific therapies to target this tumor cell population. Here, we investigate the therapeutic potential of the brain-penetrant orally bioavailable, OLIG2 inhibitor CT-179, using SHH-MB explant organoids, PDX and GEM SHH-MB models.
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GWAS and 3D chromatin mapping identifies multicancer risk genes associated with hormone-dependent cancers

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By Isela Rivera, Juliet D. French, Mainá Bitar, Haran Sivakumaran
| PLOS
Citation: Rivera IS, French JD, Bitar M, Sivakumaran H, Nair S, Kaufmann S, et al. (2024) GWAS and 3D chromatin mapping identifies multicancer risk genes associated with hormone-dependent cancers. PLoS Genet 20(11): e1011490. https://doi.org/10.1371/journal.pgen.1011490 Editor: Gregory M. Cooper, HudsonAlpha Institute for Biotechnology, UNITED STATES OF AMERICA Received: July 10, 2024; Accepted: November 6, 2024; Published: November 25, 2024 Copyright: © 2024 Rivera et al.
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GWAS and 3D chromatin mapping identifies multicancer risk genes associated with hormone-dependent cancers

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By Isela Rivera, Juliet D. French, Mainá Bitar, Haran Sivakumaran
| medRxiv
The authors have declared no competing interest. This work was supported by a grant from the Cancer Council Queensland (1156712). I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: Ethical approval was granted by the QIMR Berghofer Human Research Ethics Committee (HREC).
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