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Lachlan Harris

As seen in: Medium, Nature, MDPI, Sydney Morning Herald, The Age, The Canberra Times, Cell Reports, Cell Stem Cell, Brisbane Times, WAtoday and
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Articles

Inventing A Gridless Pathfinding Algorithm

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By Lachlan Harris
| Medium
Lachlan Harris · Follow 7 min read · -- Every single pathfinder I’ve come across is based on a grid, so I made my own tile-less one. Call me weird, but pathfinding algorithms are some of the most fun algorithms to code.
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Suppressing recurrence in Sonic Hedgehog subgroup medulloblastoma using the OLIG2 inhibitor CT-179 - Nature Communications

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By Yuchen Li, Daniel S. Malawsky, Sho Oasa, Carolin Offenhauser, Stacey Edwards, Juliet D. French, Haran Sivakumaran, Lachlan Harris, Santosh Kesari, Gregory Stein, Terrance G. Johns, Marina Sokolsky-Papkov, Lars Terenius, Vladana Vukojevic, Timothy R. Gershon, Ulrich Baumgartner
| Nature Verified
Abstract OLIG2-expressing tumor stem cells have been shown to drive recurrence in Sonic Hedgehog (SHH)-subgroup medulloblastoma (MB) and patients urgently need specific therapies to target this tumor cell population. Here, we investigate the therapeutic potential of the brain-penetrant orally bioavailable, OLIG2 inhibitor CT-179, using SHH-MB explant organoids, PDX and GEM SHH-MB models.
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Fiber-Coupled Multiplexed Independent Ho:ZBLAN Waveguide Chip Lasers in a Single Substrate

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By Dale Otten, Lachlan Harris, Dmitrii Stepanov, Yongsop Hwang
| MDPI
Open AccessCommunication by Dale E. Otten 1,*, Lachlan Harris 1, Yongsop Hwang 1, Dmitrii Y. Stepanov 2 and David G. Lancaster 1 1 STEM, University of South Australia (UniSA), Adelaide, SA 5000, Australia 2 Defence Science and Technology Group, Edinburgh, SA 5111, Australia * Author to whom correspondence should be addressed.
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