Harichandra D Tagad

Abstract TATA-box binding protein–associated factor 15 (TAF15) is an RNA-binding protein and the primary fibrillar constituent in a subset of frontotemporal lobar degeneration (FTLD) cases. However, the molecular determinants underlying TAF15 aggregation remain unclear. Here, we show that TAF15 forms amyloid fibrils under physiological conditions and develop a cellular biosensor to monitor its propagation.

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Open AccessArticle by Harichandra D. Tagad 1, Alexander Marin 1, Ruixue Wang 1, Abdul S. Yunus 1, Thomas R. Fuerst 1,2 and Alexander K. Andrianov 1,* 1 Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD 20850, USA 2 Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA * Author to whom correspondence should be addressed.