Harris Brown

Abstract Parkinson’s disease (PD) is triggered by irreversible degeneration of dopaminergic neurons in the midbrain, hypothalamus, and thalamus. Although the molecular etiology of pathology remains unclear, progressive aggregation of alpha-synuclein (α-syn) and mitochondrial dysfunction are two mechanisms implicated in neuronal degeneration.

Introduction Click to copy section linkSection link copied! Parkinson disease (PD), the fastest growing neurodegenerative disease, is projected to strike 12 million people by 2040 worldwide. (1) In the U.S., 60,000 cases of PD are diagnosed annually with estimated costs that are upward of 30 billion, making effective neuroprotective treatments an urgent and unmet need. (2) A hallmark of PD is accumulation of Lewy bodies in the midbrain, hypothalamus, and thalamus.

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