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John Walker

As seen in: Nature, The Guardian, Wiley Online Library, Patient Education and Counseling, MDPI, BioRxiv, Cell Reports, Stem Cell Reports, The Sacramento Bee, Law360 and
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Articles

A Non-randomized Phase 2 Trial of Pembrolizumab in Untreated Patients with Carcinoma of Unknown Primary Site

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By Jose Monzon, John Walker, Paul Wheatley-Price
| European Journal of Cancer Verified
Keywords CUP immunotherapy PD-L1 pembrolizumab Get full text access Log in, subscribe or purchase for full access. References 1. Raghav, K. Cancer of Unknown Primary Site N Engl J Med. 2025; 392:2035-2047 2. Rassy, E. ∙ Pavlidis, N. The currently declining incidence of cancer of unknown primary Cancer Epidemiol. 2019; 61:139-141 3. Wong, B. ∙ Liu, J. ∙ Yeo, S. ... Evolution in the diagnosis and treatment of carcinoma of unknown primary: a multicenter Canadian analysis Oncologist. 2025; 30:298 4. Lazaridis, G.
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Delayed forebrain excitatory and inhibitory neurogenesis in STRADA-related megalencephaly via mTOR hyperactivity

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By Tong Pan, Grace A. Lin, Xuan Li, John Walker, Amrita Kondur, Julie Sturza, Ken Inoki, Tomozumi Imamichi, Weizhong Chang, Louis T. Dang, Debora VanHeyningen, Sahej Kohli, Aiswarya Saravanan, Daniel C. Jaklic, Saul Pantoja-Gutierrez, Shivanshi Vaid
| Stem Cell Reports Verified
Results To avoid confounding from chromosomal abnormalities in prior PMSE patient iPSC lines (Dang et al., 2021), we used CRISPR/Cas9 to generate STRADA loss-of-function KO lines with compound heterozygous truncating variants and isogenic controls (Figures S1A and S1B). Lines expressed pluripotency markers (Figure S1C) and showed no karyotypic abnormalities (data not shown). Two STRADA KO (M1 and M2) and two isogenic control (C1 and C2) lines were used for all experiments.
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Ski2-like helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses

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By Nicole L. Batenburg, Aruna Arumugam, John Walker, sadaf Valeh Sheida, Anja-Katrin Bielinsky, Markus C. Wahl, Jean-Yves Masson, Xu-Dong Zhu, Shixin Cui
| Cell Reports Verified
Keywords ASCC2 ASCC3 replication stress PCNA ubiquitylation fork reversal ATR activation RAD51-dependent recombination genomic stability Research topic(s) CP: genomics Introduction Replication stress represents a major source of genomic instability that can drive tumorigenesis.1,2,3 Human cells have evolved several interconnected responses to replication stress.4,5,6 Upon fork stalling, the uncoupling of leading and lagging strand DNA synthesis generates single-stranded DNA (ssDNA).
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