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Harry Bartelink on Muck Rack

Harry Bartelink

As seen in: Nature, Journal of Clinical Epidemiology
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Articles

Spatial structures of tumor and immune cells shape outcomes in ER⁺HER2⁻ and triple-negative breast cancer

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By Iris Nederlof, Siamak Hajizadeh, Rolf Harkes, Bárbara Barbosa, Michiel de Maaker, Ingrid Hofland, Dennis G Peters, Annegien Broeks, Erik van Werkhoven, Yongsoo Kim, Noel de Miranda, Joyce Sanders, Roberto Salgado, Philip Martin Poortmans, Astrid N. Scholten, Liesbeth J. Boersma, Marleen Kok, Harry Bartelink, Marc J. van de Vijver, Hugo M. Horlings, Robert Elens, Marieke Ijsselstein, Sophie Bosma, Nicole C. M. Visser, Malou L. H. Snijders
| Nature Verified
Abstract Immune infiltration is prognostic in triple-negative breast cancer (TNBC), but its role in ER⁺HER2− disease remains unclear, and conventional scoring may overlook spatial context. We analyzed tumors from 1,037 women ≤50 years in the Young Boost Trial (NCT00212121), integrating centralized pathology review, deep learning-based spatial profiling of whole-slide H&E, and multiplex immunophenotyping.
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